Within the pharma industry active ingredients are commonly formulated as solid dosages, however the properties of the solid form of the actives are not always ideal. Therefore, crystal engineering is often employed to improve properties. Co-crystals are a form of crystal engineering that is gaining an increased level of interest within pharma.
Co-crystals are a multicomponent complex, similar to salts, solvates and hydrates, where a second molecule is incorporated into the crystal lattice. However, unlike other complexes, the second molecule must be neutral and not a solvent.
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