The Zeta Plus™ encapsulated system is a single-use depth filtration system designed for the bioprocessing industry where upstream cell culture clarification and impurity removal or downstream impurity reduction is required.
The primary application for the Zeta Plus encapsulated system is cell culture clarification after fermentation. The system can be employed alone or in combination with centrifugation or tangential flow filtration (TFF). An alternative application for the Zeta Plus encapsulated system is downstream impurity reduction. Taking advantage of its positive charge capacity, Zeta Plus filter media has been shown to be effective in removing contaminants such as host cell proteins (HCP), viruses, DNA, protein aggregates and endotoxins.
In monoclonal antibody production, Zeta Plus filter media is increasingly being used as a polishing step after the Protein A column capture step, replacing traditional anion exchange chromatography.
Click here to download 3M Purification’s new white paper about the Zeta Plus™ encapsulated system.