AAV-GAD is a gene therapy commercialized by MeiraGTx, with a leading Phase II program in Parkinson’s Disease. According to Globaldata, it is involved in 4 clinical trials, of which 1 was completed, 2 are ongoing, and 1 was terminated. GlobalData uses proprietary data and analytics to provide a complete picture of AAV-GAD’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
The revenue for AAV-GAD is expected to reach an annual total of $13 mn by 2037 globally based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
AAV-GAD Overview
AAV-GAD is under development for the treatment of Parkinson's disease. The therapeutic candidate is a glutamic acid decarboxylase Adeno-associated virus 2 (AAV2) gene therapy. It is administered as an infusion directly into the subthalamic nucleus.
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MeiraGTx Overview
MeiraGTx is a gene therapy company that develops treatments for ocular, salivary gland and central nervous system diseases. The company’s product pipeline includes AAV-RPGR, AAV-RPE65, AAV-CNGB3, A006, AAV-GAD, AAV-UPF1 and AAV-AQP1. Its pipeline treats X-linked retinitis pigmentosa, gene deficiency, achromatopsia, macular degeneration, parkinson’s disease, amyotrophic lateral sclerosis, radiation-induced xerostomia and ophthalmology diseases. MeiraGTx is developing riboswitch inducible expression programs targeting ophthalmology and oncology indications, diabetes and metabolic disorders among others. The company operates in the UK, the Netherlands and the US. MeiraGTx is headquartered in New York City, New York, the US.
For a complete picture of AAV-GAD’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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