Briquilimab is under clinical development by Jasper Therapeutics and currently in Phase II for Chronic Urticaria Or Hives. According to GlobalData, Phase II drugs for Chronic Urticaria Or Hives have a 52% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Briquilimab’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Briquilimab (AMG-191) is under development for the treatment of fanconi anemia, myelodysplastic syndrome, severe combined immunodeficiency, acute myeloid leukemia, sickle cell disease, chronic granulomatous disease (CGD), Gaucher disease type 1, chronic inducible urticaria (CIndU), passive systemic anaphylaxis, cockroach allergen induced allergic asthma and chronic spontaneous urticaria (CSU). The drug candidate acts by targeting stem cell growth factor receptor Kit. It is a humanized anti-c-Kit monoclonal antibody. It is administered through intravenous route and subcutaneous route. It was also under development for the treatment of inflammatory diseases such as idiopathic pulmonary fibrosis (IPF).
Jasper Therapeutics overview
Jasper Therapeutics is a biotechnology company that develops antibodies for chronic mast and stem cell diseases such as chronic urticaria and lower to intermediate-risk myelodysplastic syndromes (MDS). It also operates as a conditioning agent for stem cell transplants for rare diseases such as sickle cell disease (SCD), Fanconi anemia (FA) and severe combined immunodeficiency (SCID). It develops and commercializes stem cell engineering for expanded use of stem cell transplantation. The company pipeline products are JSP191 is in clinical development that clears hematopoietic stem cells from bone marrow. It also offers engineered hematopoietic stem cells(eHSCs) platform to address the limitations of transplant grafts and unlock the potential of stem cells. Jasper Therapeutics is headquartered in ReedWood, California, the US
For a complete picture of Briquilimab’s drug-specific PTSR and LoA scores, buy the report here.