CABA-201 is under clinical development by Cabaletta Bio and currently in Phase II for Lupus Nephritis. According to GlobalData, Phase II drugs for Lupus Nephritis have a 50% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how CABA-201’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Cabaletta Bio overview
Cabaletta Bio is a biopharmaceutical company that develops cellular therapies for the treatment of B cell-mediated autoimmune diseases. The company utilizes its platform that encompasses CARTA (chimeric antigen receptor T cells for autoimmunity) strategy and CAART (chimeric autoantibody receptor T cells) strategy. Its product pipeline includes CABA-201, a fully human CD19 chimeric antigen receptor to treat systemic lupus erythematosus, rheumatoid arthritis, myositis, and systemic sclerosis; and DSG3-CAART for the treatment of mucosal pemphigus vulgaris. Cabaletta is also investigating other programs including MuSK-CAART to treat myasthenia gravis; PLA2R-CAART against membranous nephropathy and DSG3/1-CAART for the treatment of mucocutaneous pemphigus vulgaris. The company works in collaboration with Yale, the University of California, Stanford Medicine, University of Pennsylvania among others. Cabaletta Bio is headquartered in Philadelphia, Pennsylvania, US.
For a complete picture of CABA-201’s drug-specific PTSR and LoA scores, buy the report here.