Caficrestat by Applied Therapeutics for Cardiomyopathy: Likelihood of Approval

Brought to you by GlobalData


Caficrestat is under clinical development by Applied Therapeutics and currently in Phase III for Cardiomyopathy. According to GlobalData, Phase III drugs for Cardiomyopathy have a 57% phase transition success rate (PTSR) indication benchmark for progressing into Pre-Registration. GlobalData’s report assesses how Caficrestat’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

Smarter leaders trust GlobalData

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Caficrestat overview

Caficrestat (AT-001) is under development for the treatment of diabetic complications including type 2 diabetes, diabetic cardiomyopathy, diabetic peripheral neuropathy, acute myocardial infarction (liquid formulation), acute lung inflammation and cardiomyopathy in critical COVID-19 infections. The drug candidate acts by targeting aldose reductase. It is administered through an oral and subcutaneous route. It was under development for congestive heart failure in adults.

Applied Therapeutics overview

Applied Therapeutics is a clinical-stage biopharmaceutical company that focuses on developing transformative drugs in areas Galactosemia and Diabetic Cardiomyopathy (DbCM). The company product pipeline includes include AT-001 a novel aldose reductase inhibitor, AT-007 a SORD Deficiency, AT-001 a Diabetic Peripheral Neuropathy. It also develops preclinical pipeline product AT-003, an ARI designed for the treatment of diabetic retinopathy and AT-104 a PI3K inhibitor for treating orphan hematological oncology T Cell Acute Lymphoblastic Leukaemia. It serves in the United States. Applied Therapeutics is headquartered in New York City, New York, the US.

For a complete picture of Caficrestat’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 10 June 2024

Data Insights


The gold standard of business intelligence.

Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.

More Relevant


Sign up to the newsletter: In Brief

Your corporate email address *
First name *
Last name *
Company name *
Job title *
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Thank you for subscribing

View all newsletters from across the GlobalData Media network.