Decibel Therapeutics has been granted a patent for hypertonic pharmaceutical compositions containing anti-platinum chemoprotectant agents and gelling agents. The compositions have a calculated osmolarity of 3,000-7,000 mOsm/L. The patent also covers methods of medical use for these compositions. GlobalData’s report on Decibel Therapeutics gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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Hypertonic pharmaceutical composition for anti-platinum chemoprotection
A recently granted patent (Publication Number: US11857567B2) discloses a hypertonic pharmaceutical composition designed to prevent or mitigate platinum-induced ototoxicity in subjects. The composition has a calculated osmolarity ranging from 3,000 to 7,000 mOsm/L and includes 1M-2M of an anti-platinum chemoprotectant agent, a gelling agent, and an optional tonicity agent. The osmolarity is calculated based on the chemoprotectant agent and tonicity agent, if present, with a preferred range of 3,000-5,000 mOsm/L. The anti-platinum chemoprotectant agent can be various substances such as sodium thiosulfate, amifostine, or glutathione, while the gelling agent can include hyaluronan, polyethylene glycol, or cellulose derivatives.
The method of administration involves delivering the hypertonic pharmaceutical composition intratympanically or transtympanically to the round window of the subject. This method aims to protect against platinum-induced ototoxicity caused by platinum-based antineoplastic agents. The composition can be administered before or after the platinum-based agent through a different route. The patent also covers the preparation method of the composition, involving mixing the chemoprotectant agent, gelling agent, and optional tonicity agent with a liquid solvent to achieve the desired hypertonic formulation. The patent emphasizes the importance of the specific concentrations and components in the composition to effectively prevent or mitigate platinum-induced ototoxicity.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
