EF-001 is under clinical development by Everfront Biotech and currently in Phase II for Glioblastoma Multiforme (GBM). According to GlobalData, Phase II drugs for Glioblastoma Multiforme (GBM) have a 23% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how EF-001’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

EF-001 overview

EF-001 is under development for the treatment of high grade glioma including grade III, grade IV anaplastic astrocytoma, glioblastoma multiforme (GBM) and pancreatic cancer. The drug candidate is a natural compound z-butylidenephthalide (Bdph), obtained from the chloroform extract of Angelica sinensis. The drug candidate is developed as a wafer by incorporating Bdph into a biodegradable polyanhydride material and is administered as an intracerebral implant after resection of tumor. It targets Nur77,  MGMT and PD-L1.

For a complete picture of EF-001’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 7 February 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.