The pharmaceutical industry continues to be a hotbed of innovation, with activity driven by the evolution of new treatment paradigms, and the gravity of unmet needs, as well as the growing importance of technologies such as pharmacogenomics, digital therapeutics, and artificial intelligence. In the last three years alone, there have been over 633,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Innovation in Pharmaceuticals: Knockin type transgenic animals.

However, not all innovations are equal and nor do they follow a constant upward trend. Instead, their evolution takes the form of an S-shaped curve that reflects their typical lifecycle from early emergence to accelerating adoption, before finally stabilising and reaching maturity.

Identifying where a particular innovation is on this journey, especially those that are in the emerging and accelerating stages, is essential for understanding their current level of adoption and the likely future trajectory and impact they will have.

110 innovations will shape the pharmaceutical industry

According to GlobalData’s Technology Foresights, which plots the S-curve for the pharmaceutical industry using innovation intensity models built on over 756,000 patents, there are 110 innovation areas that will shape the future of the industry.

Within the emerging innovation stage, cell therapy for ocular disorders, coronavirus vaccine components, and DNA polymerase compositions are disruptive technologies that are in the early stages of application and should be tracked closely. Adeno-associated virus vectors, alcohol dehydrogenase compositions, and antibody serum stabilisers are some of the accelerating innovation areas, where adoption has been steadily increasing. Among maturing innovation areas are anti-influenza antibody compositions and anti-interleukin-1, which are now well established in the industry.

Innovation S-curve for the pharmaceutical industry

Knockin type transgenic animals is a key innovation area in the pharmaceutical industry

Knockin mice are genetically modified mouse models in which a gene sequence is inserted at a particular locus to understand the impact of the inactivation of a particularly targeted gene function. Constitutive knockin, humanisation knockin, reporter/tag knockin, and targeted transgenics are a few examples of different knockin types that use the Rosa26 locus, which offers complete control of the gene expression. Scientists often use embryonic stem cells to insert entirely new genes into specific locations in the genome.

GlobalData’s analysis also uncovers the companies at the forefront of each innovation area and assesses the potential reach and impact of their patenting activity across different applications and geographies. According to GlobalData, there are 100+ companies, spanning technology vendors, established pharmaceutical companies, and up-and-coming start-ups engaged in the development and application of knockin type transgenic animals.

Key players in knockin type transgenic animals – a key innovation area in the pharmaceutical industry 

‘Application diversity’ measures the number of different applications identified for each relevant patent and broadly splits companies into either ‘niche’ or ‘diversified’ innovators.

‘Geographic reach’ refers to the number of different countries each relevant patent is registered in and reflects the breadth of geographic application intended, ranging from ‘global’ to ‘local’.

Patent volumes related to knockin type transgenic animals

Company Total patents (2010 - 2021) Premium intelligence on the world's largest companies
Regeneron Pharmaceuticals 2434 Unlock company profile
Sanofi 381 Unlock company profile
Ligand Pharmaceuticals 167 Unlock company profile
F. Hoffmann-La Roche 150 Unlock company profile
Biocytogen Pharmaceuticals (Beijing) 146 Unlock company profile
Recombinetics 117 Unlock company profile
Deerfield Management 92 Unlock company profile
Bristol-Myers Squibb 77 Unlock company profile
United Therapeutics 63 Unlock company profile
Merus 60 Unlock company profile
Erasmus MC 53 Unlock company profile
Kirin Holdings 48 Unlock company profile
Spectrum Brands Holdings 47 Unlock company profile
Biogen 45 Unlock company profile
E. Merck 38 Unlock company profile
Amgen 37 Unlock company profile
Takeda Pharmaceutical 36 Unlock company profile
Jackson ImmunoResearch Laboratories 34 Unlock company profile
AgGenetics 34 Unlock company profile
AbCellera Biologics 30 Unlock company profile
Crescendo Biologics 30 Unlock company profile
ImmunoGen 30 Unlock company profile
LFB 30 Unlock company profile
AstraZeneca 25 Unlock company profile
UK Research and Innovation 24 Unlock company profile
Children's Medical Center 23 Unlock company profile
Commonwealth Scientific and Industrial Research Organisation 23 Unlock company profile
Government of South Korea 22 Unlock company profile
ITI Scotland 22 Unlock company profile
Teijin 21 Unlock company profile
Helmholtz Association of German Research Centres 20 Unlock company profile
PhoenixBio 20 Unlock company profile
Vivoryon Therapeutics 20 Unlock company profile
Transposagen Biopharmaceuticals 19 Unlock company profile
Cho-A Pharm 19 Unlock company profile
Kaneka 18 Unlock company profile
Baxter International 18 Unlock company profile
SAB 18 Unlock company profile
Wellcome Trust 16 Unlock company profile
AquaBounty Technologies 16 Unlock company profile
Precigen 16 Unlock company profile
Sangamo Therapeutics 15 Unlock company profile
Japan Science and Technology Agency 13 Unlock company profile
Institut Pasteur 13 Unlock company profile
Centre National de la Recherche Scientifique 13 Unlock company profile
Pharming Group 13 Unlock company profile
Cellectis 12 Unlock company profile
Perrigo 12 Unlock company profile
Mice With Horns 12 Unlock company profile
BioProtein Technologies 11 Unlock company profile

Source: GlobalData Patent Analytics

Regeneron Pharmaceuticals is the leading patent filer for knockin type transgenic animals. Regeneron Pharmaceuticals has a market cap of $78.64bn and is primarily focused on cancer, allergic and inflammatory diseases, eye diseases, metabolic and cardiovascular diseases, infectious diseases, neuromuscular diseases, and rare diseases. Regeneron has created the VelociSuite of Technologies, comprising VelociGene, VelociMouse, VelocImmune and VelociMab. Together, these technologies increase the efficiency and decrease the time involved in the discovery and generation of drug candidates. The company’s VelociMouse technology enables the immediate generation of genetically altered mice directly from modified embryonic stem cells.

In terms of application diversity, Prothena is the top company, followed by Vivoryon Therapeutics and MannKind. By means of geographic reach, Sangamo Therapeutics holds the top position. Denali Therapeutics and Ligand Pharmaceuticals stand in second and third positions, respectively.

To further understand the key themes and technologies disrupting the pharmaceutical industry, access GlobalData’s latest thematic research report on Pharmaceutical.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Patent Analytics tracks patent filings and grants from official offices around the world. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.