The pharmaceutical industry continues to be a hotbed of patent innovation. Activity is driven by the evolution of treatment paradigms, and the gravity of unmet needs, as well as the growing importance of technologies such as pharmacogenomics, digital therapeutics, and artificial intelligence. In the last three years alone, there have been over 787,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Nanomedicine in pharma: mRNA delivery lipid nanoparticles. Buy the report here.
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According to GlobalData’s Technology Foresights, which uses over 668,000 patents to analyze innovation intensity for the pharmaceutical industry, there are 80+ innovation areas that will shape the future of the industry.
mRNA delivery lipid nanoparticles is a key innovation area in nanomedicine
The concept of messenger ribonucleic acid (mRNA) delivery lipid nanoparticles involves the use of lipid-based nanoparticles to deliver mRNA to specific cells in the body. These nanoparticles are formulated to protect the mRNA from degradation and facilitate its uptake by target cells, allowing to produce specific proteins or immunological responses.
GlobalData’s analysis also uncovers the companies at the forefront of each innovation area and assesses the potential reach and impact of their patenting activity across different applications and geographies. According to GlobalData, there are 30+ companies, spanning technology vendors, established pharmaceutical companies, and up-and-coming start-ups engaged in the development and application of mRNA delivery lipid nanoparticles.
Key players in mRNA delivery lipid nanoparticles – a disruptive innovation in the pharmaceutical industry
‘Application diversity’ measures the number of applications identified for each patent. It broadly splits companies into either ‘niche’ or ‘diversified’ innovators.
‘Geographic reach’ refers to the number of countries each patent is registered in. It reflects the breadth of geographic application intended, ranging from ‘global’ to ‘local’.
Patent volumes related to mRNA delivery lipid nanoparticles
| Company | Total patents (2021 - 2023) | Premium intelligence on the world's largest companies |
| Moderna | 336 | Unlock Company Profile |
| Sanofi | 215 | Unlock Company Profile |
| Takeda Pharmaceutical | 93 | Unlock Company Profile |
| Arbutus Biopharma | 51 | Unlock Company Profile |
| Curevac | 50 | Unlock Company Profile |
| CRISPR Therapeutics | 39 | Unlock Company Profile |
| Alnylam Pharmaceuticals | 33 | Unlock Company Profile |
| Provecs Medical | 20 | Unlock Company Profile |
| Bayer | 18 | Unlock Company Profile |
| BioNTech | 16 | Unlock Company Profile |
| Japan Science and Technology Agency | 14 | Unlock Company Profile |
| Intellia Therapeutics | 13 | Unlock Company Profile |
| Arcturus Therapeutics | 10 | Unlock Company Profile |
| Aadigen | 7 | Unlock Company Profile |
| Generation Bio | 7 | Unlock Company Profile |
| Teloregen | 7 | Unlock Company Profile |
| Adhera Therapeutics | 7 | Unlock Company Profile |
| Ramot | 5 | Unlock Company Profile |
| Avidity Biosciences | 5 | Unlock Company Profile |
| Vertex Pharmaceuticals | 3 | Unlock Company Profile |
| InnoTherapy | 3 | Unlock Company Profile |
| Centro De Investig Y De Estudios Avanzados Del I P N | 2 | Unlock Company Profile |
| RoverMed BioSciences | 2 | Unlock Company Profile |
| TRON | 2 | Unlock Company Profile |
| Eloxx Pharmaceuticals | 2 | Unlock Company Profile |
| Toshiba | 2 | Unlock Company Profile |
| Dynavax Technologies | 2 | Unlock Company Profile |
| AstraZeneca | 2 | Unlock Company Profile |
| Shenzhen People's Hospital | 2 | Unlock Company Profile |
| Protiva Biotherapeutics | 2 | Unlock Company Profile |
| Otsuka | 1 | Unlock Company Profile |
| Samsung Group | 1 | Unlock Company Profile |
| CureLab Oncology | 1 | Unlock Company Profile |
| Novartis | 1 | Unlock Company Profile |
| Zhang Yuan | 1 | Unlock Company Profile |
| ApicHope Pharmaceutical | 1 | Unlock Company Profile |
| Myeloid Therapeutics | 1 | Unlock Company Profile |
| Innorna | 1 | Unlock Company Profile |
Source: GlobalData Patent Analytics
Moderna is one of the leading patent filers in mRNA delivery lipid nanoparticles. The biotechnology company focuses on the development of mRNA therapeutics and vaccines. The company develops and discovers drugs that produce proteins or antibodies inside patient cells. Its pipeline includes various drug modalities such as prophylactic vaccines, therapeutic vaccines, intratumoral immuno-oncology candidates, localized therapeutics, and liver intracellular candidates. Moderna, through its mRNA therapeutics that are delivered using a lipid nanoparticle (LNP) technology platform, develops and produces human proteins, antibodies, and novel proteins, which help in preventing, treating, and curing diseases. Sanofi and Takeda Pharmaceutical are some of the other key patent filers in mRNA delivery lipid nanoparticles.
In terms of application diversity, Moderna leads the pack, while Avidity Biosciences and Intellia Therapeutics stood in the second and third positions, respectively. By means of geographic reach, Curevac held the top position, followed by Provecs Medical and Arbutus Biopharma.
To further understand the key themes and technologies disrupting the pharmaceutical industry, access GlobalData’s latest thematic research report on Nanotechnology in Medicine.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Patent Analytics tracks patent filings and grants from official offices around the world. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.
