Insmed. has filed a patent for methods of extracting neutrophil serine proteases (NSPs) from white blood cells (WBCs) in a subject using nonionic surfactants and repeated lysis cycles. The extracted NSPs can be used as biomarkers to guide the selection or adjustment of effective dosages for treating dipeptidyl peptidase 1 (DPP1)-mediated conditions with certain compounds. GlobalData’s report on Insmed gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Insmed, Peptide pharmacophores was a key innovation area identified from patents. Insmed's grant share as of September 2023 was 51%. Grant share is based on the ratio of number of grants to total number of patents.

Extraction of neutrophil serine proteases from white blood cells

Source: United States Patent and Trademark Office (USPTO). Credit: Insmed Inc

A recently filed patent (Publication Number: US20230310453A1) describes a method for extracting neutrophil serine proteases (NSPs) from white blood cells (WBCs) obtained from a subject. The method involves contacting the sample with aqueous mediums containing nonionic surfactants to obtain cell lysates comprising NSP extracts. The method also includes separating the cell lysates from the residual WBCs to obtain separated cell lysates comprising NSP extracts. The patent claims cover various aspects of the method, including the specific concentrations and types of nonionic surfactants used, as well as the temperature and agitation methods employed during the extraction process.

The method described in the patent is intended for the extraction of NSPs, which are enzymes involved in various physiological processes, from WBCs. The method involves contacting the WBC sample with aqueous mediums containing nonionic surfactants, which help in the extraction of NSPs. The patent claims specify the concentration of the nonionic surfactants used, which should be at least 0.01% (v/v). The patent also describes different agitation methods, such as pipetting, vortexing, shaking, and stirring, that can be used during the extraction process.

The patent claims also cover the separation of the cell lysates from the residual WBCs to obtain separated cell lysates comprising NSP extracts. The patent claims specify that the first and second separated cell lysates can be combined to provide a pooled NSP extract. The patent also describes the measurement of the concentration of active NSPs in the separated cell lysates and the pooled cell lysate.

The patent further describes the treatment of a DPP1-mediated condition in a patient using the extracted NSPs. The method involves measuring the baseline concentration of active NSPs in a sample obtained from the patient and then orally administering a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof. The patent claims cover different dosages and administration periods for the treatment.

Overall, the patent describes a method for extracting NSPs from WBCs using specific concentrations of nonionic surfactants and specific agitation methods. The patent also covers the treatment of DPP1-mediated conditions using the extracted NSPs. However, it is important to note that the patent claims are limited to the specific details mentioned in the claims and should not be interpreted beyond the scope of the claims.

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies