Lutetium Lu 177 vipivotide tetraxetan is under clinical development by Advanced Accelerator Applications and currently in Phase II for Metastatic Prostate Cancer. According to GlobalData, Phase II drugs for Metastatic Prostate Cancer have a 30% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Lutetium Lu 177 vipivotide tetraxetan’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Lutetium Lu 177 vipivotide tetraxetan overview

lutetium Lu 177 vipivotide tetraxetan (Pluvicto) is a radioligand therapeutic agent. It is formulated as solution for intravenous route of administration. Pluvicto is indicated for the treatment of  adult patients with prostate-specific membrane antigen (PSMA)-positive metastatic castration-resistant prostate cancer (mCRPC) who have been treated with androgen receptor (AR) pathway inhibition and taxane-based chemotherapy. AAA-617 (177Lu-PSMA-617) is under development for the treatment of metastatic hormone sensitive prostate cancer (mHSPC), metastatic hormone-naive prostate cancer (mHNPC). It is administered through intravenous route. The drug candidate is a small molecule (PSMA-617) which is conjugated to radioligand 177-Lu. It acts by targeting PSMA. It is a new molecular entity (NME). It was under development for the treatment of hormone-sensitive prostate cancer.

Advanced Accelerator Applications overview

Advanced Accelerator Applications (AAA), a Novartis company, is engaged in developing, producing and commercializing diagnostic and therapeutic molecular nuclear medicine products. The company develops new medicines which targets the orphan diseases in the field of cardiology, oncology, neurology and inflammation. It is also involved in manufacturing Positron Emission tomography (PET) and single-photon emission computed tomography (SPECT). It’s key brand portfolio comprises Lutathera, NETSPOT, SOMAKIT TOC, Gluscan, Gluscan 500, Barnascan, Fluorochol, AAACholine, Cholscan, Lysakare, Dopaview, Padoview and Lumark. AAA is headquartered in Rueil-Malmaison Cedex, Ile-de-France, France.

For a complete picture of Lutetium Lu 177 vipivotide tetraxetan’s drug-specific PTSR and LoA scores, buy the report here.

GlobalData

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.