MCLA-129 is a monoclonal antibody commercialized by Merus, with a leading Phase II program in Non-Small Cell Lung Cancer. According to Globaldata, it is involved in 2 clinical trials, which are ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of MCLA-129’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
The revenue for MCLA-129 is expected to reach an annual total of $201 mn by 2038 globally based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
MCLA-129 is under development for the treatment of solid tumor including non-small cell lung cancer, gastric cancer, esophageal squamous cell cancer (ESCC), gastroesophageal junction (GC/GEJ) adenocarcinoma, head and neck cancer and colorectal cancer. It is administered through intravenous drip. The therapeutic candidate is a bi-specific monoclonal antibody that acts by targeting epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (MET). The drug candidate is being developed based on Biclonics platform.
Merus is a pharmaceutical company that discovers and develops antibody therapeutics for cancer indications. The company is investigating MCLA-128, for the treatment of metastatic breast cancer and solid tumors; ONO-4685, for the treatment of autoimmune disease. It is also evaluating MCLA-158 and MCLA-129, to treat solid tumors and MCLA-145, a T-cell agonist targeting hematological malignancy and solid tumors. Merus utilizes Multiclonics, Biclonics and Triclonics technology platform for developing antibodies to treat cancer. The company works in collaboration with Incyte Corporation, Simcere Pharmaceutical Group, Ono Pharmaceutical Co., Ltd. and Betta Pharmaceuticals Co Ltd to advance its pipeline products. Merus is headquartered in Utrecht, the Netherlands.
The company reported revenues of (US Dollars) US$49.1 million for the fiscal year ended December 2021 (FY2021), an increase of 64% over FY2020. The operating loss of the company was US$90 million in FY2021, compared to an operating loss of US$75.9 million in FY2020. The net loss of the company was US$66.8 million in FY2021, compared to a net loss of US$85.5 million in FY2020. The company reported revenues of US$6.6 million for the third quarter ended September 2022, a decrease of 48.1% over the previous quarter.
For a complete picture of MCLA-129’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.