Mind Medicine MindMed. has been granted a patent for a solid oral immediate release formulation of LSD, created through lyophilization in a pre-formed mold to produce orally disintegrating tablets. The formulation includes specific excipients such as maltodextrin, hydroxypropyl methylcellulose, and mannitol or trehalose. GlobalData’s report on Mind Medicine MindMed gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Mind Medicine MindMed, Nanoparticle drug conjugates was a key innovation area identified from patents. Mind Medicine MindMed's grant share as of June 2024 was 8%. Grant share is based on the ratio of number of grants to total number of patents.
Lsd orally disintegrating tablet formulation and manufacturing method
The granted patent US12036220B2 outlines a novel formulation and method for producing an orally disintegrating LSD tablet. The tablet is created through lyophilization of a stock solution that includes specific components: maltodextrin (2-10% weight percent) as a non-gelling matrix former, hydroxypropyl methylcellulose (1-5% weight percent) as a binder, and a filler selected from mannitol or trehalose (each 2-10% weight percent). The formulation also contains LSD tartrate at less than 1% weight percent and water. The method involves flash freezing the stock solution in a pre-formed mold, followed by lyophilization, resulting in a tablet that disintegrates in less than 60 seconds.
Additionally, the patent describes the therapeutic application of the LSD tablet, particularly for individuals who may have difficulty swallowing, such as the elderly or those with dementia. The treatment method encompasses a range of conditions, including anxiety disorders, depression, and various neurological disorders. The administration of the tablet is specified to be between 0.01-1 mg of LSD, highlighting its potential for targeted therapeutic use. The inclusion of optional buffers like citrate, phosphate, or acetate in the stock solution is also noted, which may enhance the stability and efficacy of the formulation.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
