Mirum Pharmaceuticals has been granted a patent for methods of treating cholestasis in liver disease patients by administering an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI) at a dose of at least 10 µg/kg/day. Another claim involves treating cholestatic pruritus in Alagille Syndrome patients with maralixibat at a dose of 400-800 µg/kg/day. GlobalData’s report on Mirum Pharmaceuticals gives a 360-degree view of the company including its patenting strategy. Buy the report here.
According to GlobalData’s company profile on Mirum Pharmaceuticals, Molecular diagnosis biomarkers was a key innovation area identified from patents. Mirum Pharmaceuticals's grant share as of February 2024 was 48%. Grant share is based on the ratio of number of grants to total number of patents.
Treatment of cholestatic pruritus in alagille syndrome with maralixibat
A recently granted patent (Publication Number: US11918578B2) discloses a method for treating cholestatic pruritus in individuals with Alagille Syndrome (ALGS) by administering maralixibat in specific dosages. The method involves administering maralixibat in a liquid pharmaceutical composition ranging from about 0.001 mg/mL to about 16 mg/mL, at a dosage of about 400 µg/kg/day to about 800 µg/kg/day. The administration of maralixibat is recommended once daily for a period of at least 18 weeks, with options to extend the treatment duration up to 3 years.
Furthermore, the patent claims specify that the method is particularly suitable for pediatric subjects aged at least 1 year, with the administration of maralixibat recommended prior to food ingestion. The liquid pharmaceutical composition containing maralixibat can be administered orally as an oral solution or an aqueous solution, with a concentration of about 10 mg/mL of maralixibat. The method provides a detailed protocol for the effective treatment of cholestatic pruritus in ALGS patients, offering specific dosage ranges and administration guidelines for optimal therapeutic outcomes.
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