Rhenium (186Re) Obisbemeda is a small molecule commercialized by Plus Therapeutics, with a leading Phase II program in Leptomeningeal Disease (Neoplastic Meningitis, Leptomeningeal Carcinomatosis). According to Globaldata, it is involved in 7 clinical trials, of which 3 are ongoing, and 4 are planned. GlobalData uses proprietary data and analytics to provide a complete picture of Rhenium (186Re) Obisbemeda’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.

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The revenue for Rhenium (186Re) Obisbemeda is expected to reach an annual total of $81 mn by 2036 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

Rhenium (186Re) Obisbemeda Overview

Rhenium (186Re) obisbemeda is under development for the treatment of recurrent glioblastoma multiforme, kaposi sarcoma, lung adenocarcinoma, squamous cell carcinoma, breast cancer, head and neck squamous cell carcinoma, head and neck cancer, triple-negative breast cancer (TNBC), leptomeningeal peritoneal carcinomatosis, liver cancer, lung cancer, melanoma, ovarian carcinomatosis and pediatric brain cancers including ependymoma and high-grade glioma. It is administered through intertumoral, intrathecal and intraperitoneal routes. The drug candidate comprises of N, N-bis (2-mercaptoethyl)-N',N'-diethylethylenediamine (BMEDA)-chelated rhenium nanoliposomes and is being developed based on rhenium nanoliposome (RNL) technology. The drug candidate was also under development for the treatment of pediatric diffuse intrinsic pontine glioma.

Plus Therapeutics Overview

Plus Therapeutics, formerly Cytori Therapeutics Inc is a developmental-stage pharmaceutical company, which focuses on the discovery, development, and manufacturing of complex and innovative treatments for patients with cancer and other life-threatening diseases. The company’s pipeline of candidate drug products includes Doceplus, a patented albumin-stabilized Pegylated liposomal formulation of docetaxel; Doxoplus, a complex, injectable, generic Pegylated liposomal formulation of doxorubicin; BMEDA-chelated rhenium nanoliposome (RNL); and a co-encapsulated, doxorubicin and rhenium nanoliposome (DRNL). It uses a proprietary nanotechnology platform to reformulate and improve conventional chemotherapeutics. Plus Therapeutics is headquartered in Irvine, Texas, the US.
The company reported revenues of (US Dollars) US$0.2 million for the fiscal year ended December 2022 (FY2022). The operating loss of the company was US$19.7 million in FY2022, compared to an operating loss of US$12.5 million in FY2021. The net loss of the company was US$20.3 million in FY2022, compared to a net loss of US$13.4 million in FY2021. The company reported revenues of US$1.2 million for the third quarter ended September 2023, a decrease of 33.1% over the previous quarter.

For a complete picture of Rhenium (186Re) Obisbemeda’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.

This content was updated on 10 June 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.