SCG-142 is under clinical development by SCG Cell Therapy and currently in Phase I for Human Papillomavirus (HPV) Associated Cancer. According to GlobalData, Phase I drugs for Human Papillomavirus (HPV) Associated Cancer have a 76% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how SCG-142’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

SCG-142 overview

SCG-142 is under development for the treatment of cervical cancer, head and neck cancer, human papillomavirus (hpv) associated cancer, squamous cell carcinoma, vulvar cancer, penile cancer, vaginal cancer and anal cancer. The therapeutic candidate is a natural HPV-specific TCR armoured with a TGF beta receptor type 2 (TGFbetaRII) – tumor necrosis factor receptor superfamily member 9 (4-1BB) chimeric switch receptor. It acts by targeting TGF beta receptor type 2 (TGFbetaRII) and  tumor necrosis factor receptor superfamily member 9 (4-1BB). It is developed based on GianTCR therapy platform.

SCG Cell Therapy overview

SCG Cell Therapy (SCG) is a biotechnology company that discovers and develop novel immunotherapies to treat pathogenic infections and associated cancers. It developed proprietary T-cell receptor (TCR) screening platform to identify high affinity and high avidity natural TCRs that can recognize peptide-major histocompatibility complex (pMHC) ligand and trigger cell-mediated immune response. The company is investigating its pipeline products including SCG101 which treats hepatocellular carcinoma, chlolangio carcinoma and chronic hepatitis B; SCG142 treats cervical, head and neck cancer; SCG162, SCG452 for solid tumor. It operates in China, Singapore and Germany. SCG is headquartered in Singapore City, Singapore.

For a complete picture of SCG-142’s drug-specific PTSR and LoA scores, buy the report here.

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.