SI-544 is under clinical development by SelectION and currently in Phase I for Psoriatic Arthritis. According to GlobalData, Phase I drugs for Psoriatic Arthritis have an 84% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how SI-544’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

SI-544 overview

SI-544 is under development for the treatment of cutaneous T-cell lymphoma, atopic dermatitis, plaque psoriasis, psoriatic arthritis and rheumatoid arthritis. It acts by targeting potassium voltage-gated channel subfamily A member 3 (Kv1.3). It was also under development for the treatment of vasculitis and psoriasis. It is administered through subcutaneous route.

SelectION overview

selectION is a biotechnology company that develops novel peptide therapies to treat cancer, autoimmune diseases and other ion channel-related disorders. Its product pipeline includes si-544 and LS-04. The company also offers Kv1.3 blocker targeting (CTCL) cutaneous T cell lymphoma and other effector memory T cell (TEM) driven diseases; and LS-04 for the treatment of pains. The company utilizes its proprietary phage display platform to detect highly selective peptide blockers for ion channels. selectION works in partnership with the Center for Experimental Surgery at the Hospital Groshadern, Munich, Germany. It has operational presence in Munich, Germany. selectION is headquartered in San Diego, California, the US.

For a complete picture of SI-544’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 10 June 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.