Tipifarnib is a small molecule commercialized by Kura Oncology, with a leading Phase III program in Peripheral T-Cell Lymphomas (PTCL). According to Globaldata, it is involved in 56 clinical trials, of which 46 were completed, 3 are ongoing, 1 is planned, and 6 were terminated. GlobalData uses proprietary data and analytics to provide a complete picture of Tipifarnib’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
The revenue for Tipifarnib is expected to reach an annual total of $30 mn by 2034 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
Tipifarnib Overview
Tipifarnib (Zarnestra) is under development for the treatment of relapsed/refractory peripheral T cell lymphoma (PTCL), clear cell renal cell carcinoma, recurrent head and neck cancer squamous cell carcinoma. The drug candidate is administered orally. It is a nonpeptidomimetic quinolinone. Tipifarnib is an inhibitor of farnesylation, a key cell signaling process implicated in cancer initiation and development.
It was also under development for the treatment of solid tumor, relapsed or refractory multiple myeloma, acute myeloid leukemia, advanced pancreatic cancer, higher risk myelodysplastic syndrome, breast cancer, glioblastoma multiforme, relapsed /refractory lymphomas including diffuse large b-cell lymphoma, mantle cell lymphoma, sezary syndrome , Hodgkin lymphoma, mycosis fungoides, extranodal marginal zone B-cell lymphoma (mucosa-associated lymphoid tissue or malt-lymphoma),nodal marginal zone B-cell lymphoma, splenic marginal zone b-cell lymphoma,refractory anemia with excess blasts in transformation and anaplastic large cell lymphoma, recurrent head and neck cancer squamous cell carcinoma including oral cavity, pharynx, larynx, sinonasal, nasopharyngeal, or unknown primary) and Hepatitis Delta virus (HDV) infections, non-small cell lung cancer, salivary gland cancer, angioimmunoblastic T-cell lymphoma, thyroid/solid tumors with HRAS mutations, follicular T-cell lymphoma (FTCL), extranodal natural killer T-cell lymphoma, lower risk myelodysplastic syndrome, undifferentiated myeloproliferative disorders, chronic myelocytic leukemia, chronic myelomonocytic leukemia (CMML) and HRAS mutant urothelial cancer.
Kura Oncology Overview
Kura Oncology is a biopharmaceutical company that primarily focuses on the discovery and development of precision medicines for cancer treatment. Its main activities include the design of novel therapies that selectively target cancer cells, aiming to increase clinical benefits and address areas with high unmet needs. The company’s major products are its pipeline of precision medicines, including Ziftomenib, Tipifarnib, and KO-2806. Kura Oncology’s products are primarily used in the healthcare industry, specifically in the treatment of blood cancers and solid tumors. The company’s target market appears to be patients with cancer, particularly those with blood cancers and solid tumors. Kura Oncology is headquartered in San Diego, California, the US.
The operating loss of the company was US$165.8 million in FY2023, compared to an operating loss of US$139.9 million in FY2022. The net loss of the company was US$152.6 million in FY2023, compared to a net loss of US$135.8 million in FY2022.
For a complete picture of Tipifarnib’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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