Twist Bioscience has been granted a patent for methods and compositions involving a polymerase and phosphorylated nucleoside linked by a cleavable linker. The invention allows for enzymatic polynucleotide synthesis using novel nucleotide conjugation strategies. GlobalData’s report on Twist Bioscience gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Twist Bioscience, Water gas shift catalysts was a key innovation area identified from patents. Twist Bioscience's grant share as of April 2024 was 18%. Grant share is based on the ratio of number of grants to total number of patents.

Covalently linked polymerase and phosphorylated nucleoside for polynucleotide synthesis

Source: United States Patent and Trademark Office (USPTO). Credit: Twist Bioscience Corp

The granted patent (Publication Number: US11970697B2) discloses a composition and method for synthesizing polynucleotides. The composition includes a complex with a specific formula and a linker that may contain at least one phosphate. The enzyme in the composition is attached to the linker via a cysteine. The linker can be of various types such as acid labile, base labile, pH-sensitive, or enzymatically-cleavable, among others. The enzyme may have a cysteine mutation, and the polymerase used is template independent. The method involves contacting a polynucleotide with the composition, extending the polynucleotide by adding an extension nucleotide, and then cleaving the enzyme from the polynucleotide.

Furthermore, the patent also covers another composition with a different formula and similar characteristics. This composition includes a complex with a linker that may contain at least one phosphate and can be enzymatically-cleavable. The enzyme in this composition may have amino acid mutations, and a reversible terminator may also be present. The base in this composition can include adenine, cytosine, guanine, thymine, uracil, or modified bases. The composition and method described in the patent offer a novel approach to synthesizing polynucleotides efficiently and accurately, with the potential for various applications in the field of molecular biology and genetic research.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies