Twist Bioscience has been granted a patent for methods and compositions involving polymerase and phosphorylated nucleosides linked by a cleavable linker. The invention allows for enzymatic polynucleotide synthesis using novel nucleotide conjugation strategies. GlobalData’s report on Twist Bioscience gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Twist Bioscience, Water gas shift catalysts was a key innovation area identified from patents. Twist Bioscience's grant share as of May 2024 was 11%. Grant share is based on the ratio of number of grants to total number of patents.
Covalently linked polymerase and phosphorylated nucleoside for polynucleotide synthesis
A recently granted patent (Publication Number: US11970697B2) discloses a composition comprising a complex with a specific formula, where the linker may contain at least one phosphate and the enzyme can be attached to the linker via a cysteine. The composition includes various types of linkers such as acid labile, base labile, pH-sensitive, and enzymatically-cleavable linkers, among others. Additionally, the enzyme in the composition may have a cysteine mutation and the polymerase may have amino acid mutations. The method described in the patent involves synthesizing a polynucleotide by extending it with an extension nucleotide using the enzyme and then cleaving the enzyme from the polynucleotide.
Furthermore, the patent also covers a composition with a different formula, A-L-B, where the linker can include various types of linkers like enzymatically-cleavable linkers and the enzyme may have amino acid mutations. The complex may also include a reversible terminator and bases such as adenine, cytosine, guanine, thymine, uracil, and modified bases. The composition can be used in methods for synthesizing polynucleotides by extending them with extension nucleotides and cleaving the enzyme from the polynucleotide, with the possibility of repeating the process to produce an extended polynucleotide. Overall, the patent provides a detailed description of compositions, methods, and components involved in the synthesis of polynucleotides, offering a valuable contribution to the field of molecular biology and genetic research.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
