Wave Life Sciences has been granted a patent for oligonucleotides, compositions, and methods for treating C9orf72-related disorders. The patent claims an oligonucleotide composition with specific base sequences, backbone linkages, and backbone chiral centers, enriched for oligonucleotides of a particular type. The composition includes oligonucleotides with different sugar modifications and a core structure containing specific phosphorus configurations. The patent highlights the impact of these structural elements on the properties and activities of the oligonucleotides. GlobalData’s report on Wave Life Sciences gives a 360-degree view of the company including its patenting strategy. Buy the report here.
Smarter leaders trust GlobalData
Discover B2B Marketing That Performs
Combine business intelligence and editorial excellence to reach engaged professionals across 36 leading media platforms.
According to GlobalData’s company profile on Wave Life Sciences, siRNA gene silencing was a key innovation area identified from patents. Wave Life Sciences's grant share as of September 2023 was 24%. Grant share is based on the ratio of number of grants to total number of patents.
Patent granted for oligonucleotide composition with specific structural characteristics
A recently granted patent (Publication Number: US11739325B2) describes an oligonucleotide composition that is enriched for a specific type of oligonucleotide. The composition is characterized by a common base sequence, a common pattern of backbone linkages, and a common pattern of backbone chiral centers. Each oligonucleotide of the particular type consists of a first wing, a second wing, and a core in a specific format. The first wing and second wing have different sugar modifications, and the core contains (Op)n(Sp)m, where Op represents an achiral linkage phosphorus of a natural phosphate linkage with a 5'-modification on its sugar, and Sp indicates the S configuration of a chiral modified internucleotidic linkage. The composition can be used to decrease the level, expression, and/or activity of a target gene or its product.
The patent also discloses various embodiments and methods related to the oligonucleotide composition. These include variations in the sugar modifications of the first and second wings, the internucleotidic linkages, and the stereochemistry of the internucleotidic linkages. The composition can comprise five or more chirally controlled internucleotidic linkages. Additionally, the patent describes methods for selective suppression of a target nucleic acid sequence and allele-specific suppression of a target nucleic acid sequence. These methods involve contacting a sample comprising transcripts of the target nucleic acid sequence with the chirally controlled oligonucleotide composition, where the common base sequence of the oligonucleotides is complementary to a characteristic sequence element that defines the target nucleic acid sequence or a particular allele.
Furthermore, the patent discloses a method for reducing the level of a transcript or a protein encoded by the transcript in a system by administering the oligonucleotide composition.
Overall, this patent describes an oligonucleotide composition enriched for a specific type of oligonucleotide and its various applications in gene suppression and reducing the level of transcripts or proteins. The composition's unique characteristics, such as the specific sugar modifications and chiral linkages, make it a potentially valuable tool in molecular biology and therapeutic applications.
To know more about GlobalData’s detailed insights on Wave Life Sciences, buy the report here.
Data Insights
From
The gold standard of business intelligence.
Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors.
GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
