Zelebrudomide is a small molecule commercialized by Nurix Therapeutics, with a leading Phase I program in Primary CNS Lymphoma. According to Globaldata, it is involved in 1 clinical trial, which is ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of Zelebrudomide’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
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The revenue for Zelebrudomide is expected to reach an annual total of $109 mn by 2036 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
Zelebrudomide Overview
zelebrudomide (NX-2127) is under development for the treatment of relapsed and refractory B-cell malignancies including Non-Hodgkin's lymphoma including relapsed chronic lymphocytic leukemia (CLL), marginal zone B-cell lymphoma, Waldenstrom macroglobulinemia (lymphoplasmacytic Lymphoma), mantle cell lymphoma, follicular lymphoma, primary CNS lymphoma and diffuse large B-Cell lymphoma. It is administered through oral route. The drug candidate is a BTK PROTAC (proteolysis-targeting chimera degrader) and also is a molecular glue for IKZF1/3 degradation.
It was also under development for the treatment of unspecified cancer.
Nurix Therapeutics Overview
Nurix Therapeutics, formerly Nurix Inc, is a biopharmaceutical company that discovers, develops and commercializes small molecule drugs to treat cancer and autoimmune diseases. It is investigating NX-2127, a Bruton’s tyrosine kinase (BTK) inhibitor against B-cell malignancies; NX-5948 drug for the treatment of B-cell malignancies and autoimmune diseases; NX-1607, a ligase inhibitor for immune-oncology indications; and DeTIL-0255 program targeting tumor-infiltrating lymphocytes. The company is also evaluating KINASE-CTM3 against T-cell malignancies and autoimmune diseases; and COVID-CTMs for anti-viral infections. Nurix employs DELigase platform technology to modulate targeted proteins and also destroy disease-causing proteins by harnessing the activity of specific E3 ligases. The company works in collaboration with Sanofi and Gilead Sciences to develop its products. Nurix is headquartered in San Francisco, California, the US.
The company reported revenues of (US Dollars) US$77 million for the fiscal year ended November 2023 (FY2023), an increase of 99.3% over FY2022. The operating loss of the company was US$155.1 million in FY2023, compared to an operating loss of US$183.9 million in FY2022. The net loss of the company was US$144 million in FY2023, compared to a net loss of US$180.4 million in FY2022.
For a complete picture of Zelebrudomide’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.
The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.
