Silicones are used in pharmaceutical applications as part of formulations, as well as during manufacturing and in packaging.
The term ‘silicones’ encompasses a large number of compounds based on polydialkylsiloxanes. The most common are trimethylsilyloxyterminated polydimethylsiloxane.
Dimethicones and simethicones are used as active ingredients and antifoaming agents in numerous anti-flatulent or anti-acid formulations. In pharmaceutical formulations, while considered active ingredients, their effect is usually caused by their physical properties, as polydimethylsiloxanes are not metabolised.
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