FUNDAMIX® for Blood Plasma Fractionation

In plasma fractionation, the speed at which ethanol and acid are distributed determines both the yield and the purity of each protein fraction. This application paper explains how mixing affects cold ethanol fractionation, from cryoprecipitation to albumin recovery. Slow distribution causes local overdosing and lower purity, while adding acid too fast precipitates proteins that will not redissolve. The FUNDAMIX® Vibro-Mixer moves large liquid volumes with low shear, homogenising the batch quickly without damaging the precipitates. Ethanol and acid can be dosed directly into the mixing flow through a hollow shaft, so they are distributed as they are added. The paper also covers installations on sterile tanks of several thousand litres, the membrane sealing concept that replaces mechanical seals and magnetic drives, and the link to candle filtration for collecting the precipitated proteins. A practical note explains why fibrin must be removed before mixing whole blood.