Clear Creek Bio and the US National Institutes of Health (NIH) unit National Center for Advancing Translational Sciences (NCATS) have entered a cooperative research and development agreement (CRADA) for the development of an inhibitor of SARS-CoV-2 papain-like protease (PLpro).
A coronavirus enzyme, PLpro is required for replication of the virus and controls host innate immune responses to the infection.
The company noted that the potent PLpro inhibitors possess favourable drug properties.
The agreement started as part of the Antiviral Program for Pandemics (APP) and will aid Clear Creek Bio to develop promising therapies, including the completion of studies required for seeking Investigational New Drug (IND) status.
Through the deal, the existing and extended contract resources of the NIH and NCATS laboratories will be leveraged by the company to progress antiviral candidate development and de-risk initial stage development.
How well do you really know your competitors?
Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.
Thank you!
Your download email will arrive shortly
Not ready to buy yet? Download a free sample
We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form
By GlobalData
Clear Creek Bio Corporate Development vice-president Nadim Shohdy said: “There’s a critical need for widespread availability of highly effective oral antivirals that can be taken at home early in the course of infection, significantly reduce transmission of the virus and prevent overwhelming surges in hospitalisations, ultimately saving lives.
“It’s clear that we will need direct-acting antivirals against multiple SARS-CoV-2 targets to combat variant-driven resistance.”
The company specialises in host-targeting and direct-acting small-molecule antiviral drugs that act on SARS-CoV-2 as well as various other viruses.
Brequinar, the first therapy candidate of Clear Creek Bio, has potent antiviral activity against various viruses, including SARS-CoV-2.
In November last year, Clear Creek Bio dosed the first subject in the Phase II CRISIS2 trial of brequinar for treating individuals with Covid-19 in the outpatient setting.
Brequinar is an orally available drug that can specifically hinder small molecule dihydroorotate dehydrogenase (DHODH).
