Swiss pharmaceutical company Novartis has established a global clinical programme, Fortifying Heart Failure clinical evidence and patient quality of life (FortiHFy), to address the heart failure disease area across the pharmaceutical industry.

The programme involves more than 40 active or planned clinical studies designed to create an array of additional data on efficacy, symptom reduction and quality of life benefits, as well as precise evidence with its heart failure medicine Entresto (sacubitril / valsartan).

Go deeper with GlobalData

Premium Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

Novartis drug development global head and chief medical officer Dr Vas Narasimhan said: "The FortiHFy programme reinforces our long-term commitment to improving heart failure treatment for as many people as possible.

"The outcomes of these trials will increase our understanding of heart failure, the patient population who may benefit from Entresto, and could potentially support applications to regulatory authorities."

"The FortiHFy programme reinforces our long-term commitment to improving heart failure treatment for as many people as possible."

Entresto needs to be taken twice daily and helps reduce the stress on a failing heart by increasing the protective neurohormonal systems of the heart (NP system), while simultaneously reducing the harmful effects of the overactive renin-angiotensin-aldosterone system (RAAS).

See Also:

The primary trials under the FortiHFy programme include Paragon-HF, Parardise-MI, Transition, and Pioneer.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Paragon-HF will study the efficacy, as well as safety of Entresto in heart failure patients with preserved ejection fraction.

Parardise-MI will test the hypothesis that Entresto has the potentiality to reduce instances of heart failure hospitalisations, cardiovascular death and new onset heart failure in patients at high risk for heart failure after a myocardial infarction.

The transition trial will help compare in-hospital initiation of Entresto with initiation after hospital discharge in heart failure patients with reduced ejection fraction (HFrEF) who have recently been hospitalised for severe decompensation.

Pioneer will examine the effect of in-hospital initiation of Entresto on changes in NT-proBNP, compared to enalapril in patients suffering from HFrEF after a severe decompensation.

Entresto is currently approved in 57 countries across the globe to be used for the treatment of heart failure with reduced ejection fraction (HFrEF).