German-based biopharmaceutical company Probiodrug has entered into an agreement with the Dutch biotech company Crossbeta Biosciences, to use the latter’s proprietary technology in support of Probiodrug’s biomarker development activities for Alzheimer’s disease (AD).

AD is a neurological disorder and is the most common form of dementia, eventually leading to death.

Go deeper with GlobalData

Premium Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

Crossbeta chief executive officer Guus Scheefhals said: "This strategic partnership with Probiodrug is very exciting and an important recognition of our expertise and capabilities.

"As a clinical-stage company, Probiodrug is a particularly important partner in our growing collaborative network. We look forward to contributing towards the development of this promising therapeutic approach targeting AD."

"This strategic partnership with Probiodrug is very exciting and an important recognition of our expertise and capabilities."

AD currently affects about 26 million people worldwide, and is characterised by misfolded beta-amyloid and tau proteins.

See Also:

The oligomeric forms of these proteins play an important role in the patho-physiology of the disease.

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Probiodrug chief development officer Inge Lues said: "We are very pleased to announce the collaboration with Crossbeta.

"The potential of Crossbeta’s unique technology has significant impact to overcome the challenge of establishing and validating sensitive and specific assays for Abeta-oligomers and pGlu-Abeta-oligomers to be used in the clinical studies of Probiodrug’s lead candidate, Glutaminyl Cyclase (QC) inhibitor PQ912."

Oligomer-specific research and development (R&D) of therapeutics, biomarkers and diagnostics is very challenging because of the inherent instability of the protein aggregates.

The proprietary stabilisation technology provided by Crossbeta helps generate pure and functional preparations of oligomeric protein species.

This helps overcome the problem and allow highly reproducible and well-controlled assays for pre-clinical and clinical R&D.