Researchers from the UK’s University of Bath have developed a new biochip device, which will enable the discovery new life-saving drugs more quickly and cost-effectively.
The PhosphoSense technology is being used to screen compounds for use in drugs and it has created a new way to detect the activity of enzymes known as kinases.
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Kinases regulate multiple biological processes in normal healthy human cells that are required for survival, and will cause life-threatening diseases such as cancer, autoimmune disorders, Alzheimer’s and diabetes, when these become over-active or disregulated.
The new PhosphoSense biochip will help pharmaceutical firms to simultaneously measure a large number of compounds and select what can be developed into drugs to battle against diseases.
It has been developed by a researcher team that includes Dr Pedro Estrela, Nikhil Bhalla, Dr Mirella Di Lorenzo and Dr Giordano Pula.
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University of Bath Department of Pharmacy and Pharmacology lecturer Dr Giordano Pula said: "This technology has the potential to change the drug discovery process as we know it and facilitate the development of new drugs for diseases like cancer, stroke and dementia.
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By GlobalData"The simplicity is the strength of this technology. This discovery significantly simplifies the analysis of protein kinase activity and frees it from the use of radioisotopes or antibodies."
"The free-flow of information between departments at the University of Bath promoted this collaboration and the work leading to this discovery, which was a truly interdisciplinary endeavour."
The research team is currently planning to collaborate with industrial partners to develop the system to a prototype, which can be used by the pharmaceutical industry.
Image: University of Bath researchers have developed a new biochip device for life-saving drug discoveries. Photo: courtesy of University of Bath.
