ZyVersa’s cholesterol efflux mediator VAR 200 will be used to treat diabetic nephropathy/diabetic kidney disease. Credit: Boonyarit Cheunsuchon/ Flickr (Creative Commons).

ZyVersa Therapeutics has received a notice of intention to grant from the European Patent Office for its patent application for the cholesterol efflux mediator VAR 200 (2-hydroxypropyl-beta-cyclodextrin).

The application was filed for the treatment of diabetic nephropathy/diabetic kidney disease.

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The Phase IIa-ready VAR 200 is being developed to reduce renal cholesterol and the lipid accumulation that damages the filtration system of kidneys in glomerular diseases patients.

Glomerular diseases include focal segmental glomerulosclerosis, Alport syndrome and diabetic kidney disease.

VAR 200 works by removing the extra lipids from the kidney. It has the potential to reduce proteinuria and to delay the progression of renal disease.

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Its lead indication is to treat focal segmental glomerulosclerosis (FSGS), an orphan renal disease.

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ZyVersa Therapeutics co-founder, chairman, CEO and president Stephen Glover stated: “Approval of this patent claiming our cholesterol transport mediator VAR 200 for use in treating diabetic kidney disease speaks to our unique therapeutic approach involving removal of excess cholesterol and lipids that damage the kidneys’ filtration system.

“There are no therapeutic options available that address this issue.

“Strengthening our intellectual property portfolio for VAR 200 and expanding our patent protection and exclusive rights into additional geographic regions will further enable ZyVersa to increase shareholder value as VAR 200 advances into clinical trials, which are planned for initiation in the fourth quarter of this year” (2023).