Combino Pharm - Contract Manufacturing of Generic Pharmaceutical Products and APIs

Combino Pharm is a pharmaceutical company which belongs to Corporación Medichem, a privately held group of companies active in the chemical and pharmaceutical business through its two own subsidiaries, Medichem and Combino Pharm.

Combino Pharm was founded in 1996 and since then has been devoted to developing and marketing generic medicines for both the retail and the hospital markets.

The opening of Combino's own production plant in Malta in 2006, approved by the health authorities in the EU, allowed the company to improve its services, in flexibility and customer-orientated services, and opened new opportunities not only in contract manufacturing but also in supplying products manufactured in the EU from a location where day-zero launches and early entries can be managed.

Combino Pharm offers the following contract manufacturing services from its plant in Malta:

• Manufacture of products in solid oral dosage form
• Tablets: coated / uncoated, immediate or modified release
• Hard shell capsules: powders, immediate release beads, modified release beads, granules
• Blister packaging
• Pharmaceutical contract support services
• Pharmaceutical product development

Manufacture and blister packaging of oral solid dosage forms

Combino Pharm's manufacturing plant in Malta covers an area of over 6,600m² and is equipped with state-of-the-art technology. Coupled with the implementation of streamline six-sigma concepts throughout the manufacturing process, this affords an efficient, responsive and flexible service. The plant is licensed for the manufacture and blister packaging of products in oral solid dosage forms, including investigational medicinal products, in line with European Union good manufacturing practice standards.

Contract manufacturing services

The joint efforts of pharmaceutical experts at corporate level and those within the manufacturing plant ensure that any project can be undertaken, from sourcing of the API to commercial launch within pre-determined, agreed timelines.

Pharmaceutical contract manufacturing support services

Combino Pharm offers a range of pharmaceutical contract manufacturing support services. Our team incorporates expertise and knowledge into technology transfer, process development, manufacturing quality control and quality assurance, fully supported by specialists in regulatory affairs, logistics, planning, engineering and purchasing.

The regulatory affairs department has experience in obtaining marketing authorisations worldwide offering full support to the customers during the registration process.

Pharmaceutical product development

Through our R&D department we also offer pharmaceutical product development:

• Development of formulation and analytical methods
• Process development: from formulation up to validation stage
• Analytical method development and validation
• Manufacture of clinical trial materials
• QC and stability testing programmes

About Combino Pharm

Since its foundation in 1996 the company has been devoted to developing and marketing generic medicines for both the retail and the hospital market. All of those products are offered for out-licensing around the world. In addition, you can find Combino Pharm's products under Combino's brand name in Spain and, as of 2009, also in Portugal.

In the hospital area Combino Pharm was the first company to market generics in Spain and it has become an important player and a reference in that area.

The in-house development projects are offered for out-licensing covering both the primary care and the hospital market. Combino Pharm proposes flexible business models such as out-licensing agreements, distribution agreements, co-developments or technology transfer collaborations.

Furthermore, Combino Pharm meets its customers' needs, offering the company's full legal and technical know-how and understanding of the regulatory and patent systems, to launch products successfully around the world.

With a current portfolio of 28 active ingredients sold in 80 dosage forms, and a current pipeline of 15 products, Combino Pharm has established itself as a leading company in its sector.