Micron Technologies - Global, cGMP Micronizing and Milling for the Pharmaceutical IndustryOur contract powder size reduction services are exclusively for the pharmaceutical industry. Micronizing (defined as particles smaller than 20µm) often enhances solubility and improves bioavailability, allowing you to optimize the formulation of your product and reduce the therapeutic dose. With a reproducible and controlled particle size of your active pharmaceutical ingredients and excipients, manufacturing of you finished dosage form could be improved. PARTICLE SIZE REDUCTION - MICRONIZATION AND MILLINGThe most commonly used pieces of equipment are tangential fluid energy mills or pancake mills. High-pressure air / gas is introduced causing particle-to-particle collision and micronization. Micron Technologies utilizes over 20 years' experience and a wide range of equipment to consistently produce particles in the 1 to 20 micron range. We can process as little as 1g of material, through scale up to commercial volumes. Micron's expertise also extends into specialized milling technologies such as opposed jet micronization. When the size specification for a powder does not require micronization, mechanical milling is ideal for achieving consistent particle sizes above 20 microns. PARTICLE CLASSIFICATION With classification mills, inert gas is injected through specially designed nozzles directly into the grinding chamber of the mill. Raw material is introduced into the mill. Size reduction is accomplished by collisions between particles. Small particles are then swept towards the classifier, which rotates at high speeds above the grinding chamber. Material which is fine enough to pass through the classifier is collected as product. Oversized particles are recycled, by the classifier, back into the grinding chambers for further reduction. PARTICLE SIZE ANALYSISMonitoring of particle size reduction is typically performed using laser diffraction. This technique can be relatively simple and fast, making such methods ideal for in-process testing. Micron Technologies uses its knowledge and vast experience to develop reproducible and robust methods. In cases where particle size will be used as a release specification, thorough method development and validation studies are required. Method transfer studies must also be performed when using contract manufacturers. All these requirements can be serviced the Micron Technologies Laboratory. MATERIAL CHARACTERIZATION "Information regarding the comprehensive characterization of the physical and chemical properties of the drug substance should be included in the application. Important properties of the drug substance can include density, particle size distribution, particle morphology, solvates and hydrates, polymorphs, amorphous forms…" ANALYTICAL SERVICES Using a wide range of material characterisation techniques, Micron can provide valuable information on the physical properties of a material.
QUALITY ASSURANCE Good Manufacturing Practice (GMP) is an integral part of every process at Micron Technologies. Compliance is expected in the areas of validation (for example particle size methods, computers and instrumentation), employee training and documentation. Each plant has a quality assurance group which oversees every facet of the business that could impact on quality. All internal documentation is fully reviewed and your product is only released after a full QA check. The equipment we use for your project is released by QA after a 100% cleaning verification programme.
Micron Technologies
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![]() Micron Technologies offers a truly international, state-of-the-art cGMP particle size reduction service dedicated to serving the needs of the global pharmaceutical industry. | ||
![]() We own two directly compatible facilities, one based in the UK and the other in the USA. | |||
![]() At Micron Technologies we are dedicated to the efficient processing of customers' materials, ensuring the maintenance of the highest quality standards. | |||
![]() We carry out a broad range of analytical services, including polymorph and amorphous information. | |||
![]() We believe in maintaining the highest standards of Good Manufacturing Practice and complying with the current requirements of the regulatory authorities. |
