Sartorius Group - Filtration, Purification, Separation, Ultrafiltration, Microbiology, Cell Culture, Weighing and Automation

Sartorius is an internationally leading laboratory and process technology supplier covering the segments of biotechnology and mechatronics. Its biotechnology segment focuses on filtration, purification and separation technologies, bioreactors and proteomics for the bio-pharmaceutical industry. The mechatronics segment manufactures equipment and systems, which features weighing, measurement and automation technology for laboratory, industrial, and hydrodynamic bearings applications.

PROTEIN AND PROCESS PURIFICATION

Sartorius Purification Technologies cover all relevant unit operations in modern downstream processing such as cell harvesting, capturing and polishing, viral clearance and contaminant removal for all process scales. Application specialists support you to integrate all technologies into your process to increase yields, speed up time to market and improve overall process security.

We manufacture Sartocell filter modules and Sartoclear filter sheets that enable cell harvesting and clarification after fermentation and cell culture. The Sartobind SingleSep and MultiSep membrane adsorbers, featuring disposable or process scale membrane chromatography technology, are ideally suited for contaminant removal or protein purification activities.

LABORATORY PROTEIN PURIFICATION

The Vivapure range of laboratory protein purification products is based on powerful membrane adsorber technology that enables fast, reproducible and scalable results. The purification tools include a variety of centrifugal devices using metal chelate, ion exchange, C18 and Protein-A functional groups. Vivapure spin columns are available as ready-to-use kits and as stand-alone devices.

The Vivapure® AdenoPACK™ 100 and 500 are ready-to-use kits that offer fast and efficient Adenovirus purification. Vivapure® C18 Micro spin columns are ideally suited for the preparation of mass spectrometry samples such as MALDI, MALDI-TOF and ESI samples.

Finally, the ready-to-use Vivapure Anti-HSA/IgG kit is designed to improve biomarker detection. It utilises a combination of a unique Anti-HSA antibody fragment and Protein G resin for depleting albumin and IgG from human samples.

LABORATORY ULTRAFILTRATION

The ultrafiltration units form a comprehensive range of process alternatives for the filtration and concentration of biological samples. Vivaspin, Vivaflow, Vivacell, Vivapore and Vivaclear products cover a broad choice of volume capacities and a variety of pore sizes to offer an optimal solution for any kind of concentration or buffer exchange task.

Vivaspin centrifugal ultrafiltration devices give rise to the highest flow rates and recoveries due to their particular vertical membrane design. The patented dead-stop technology allows the direct recovery of concentrate without any re-spin, and assures exceptionally safe and convenient sample handling capability. A complete line of laboratory centrifuges - from micro-centrifuges for 0.2ml PCR vessels to high-speed centrifugation of large volumes of up to 12L, with and without cooling option - complements the centrifugal product portfolio.

MICROBIOLOGY, MICROBIOLOGICAL MONITORING AND STERILITY TESTING

Sterility testing and air monitoring are crucial steps in quality control that must be taken to ensure the safety of drug products in the pharmaceutical and biotech industry. Microbiological quality control is an important industrial application that helps to maintain the safety of pharmaceutical products, beverages, cosmetics and drinking water. The Sartorius Group offers a complete range of membrane filtration solutions for efficient and reliable sterility testing, air monitoring and bacteria detection in liquid samples.

The main products include Sterisart, a completely closed system for the sterility testing of pharmaceutical products and MD 8 Airport / MD 8 Airscan, two gelatine filter-based air monitoring methods.

We supply Microsart e.motion fully automated membrane dispensers with ergonomic design, dehydrated culture media and membranes, nutrient pad sets, ampouled media and ready-to-use sterile packed membranes. We also manufacture stainless steel manifolds for vacuum filtration and Biosart 100 / 250, ready-to-use monitors and filter funnels.

CELL CULTURE

From incubators to different-sized, single-use bioreactors, Sartorius provides well thought-out solutions. Biostat®, a compact, autoclavable laboratory fermenter / bioreactor system, with application-driven configured packages for microbial culture and cell culture, is the answer to labscale fermentation. CERTOMAT® incubation shakers provide a temperature controlled environment for cell cultivation in microbiology, cell biology, and other application fields.

PROCESS FILTRATION TECHNOLOGY

Sartorius process filtration technology offers integrated solutions for media preparation, handling and storage, pre-filtration, sterile filtration, mycoplasma removal and integrity testing for the biopharmaceutical industry in all scales. Clear focus is on economic process solutions incorporating disposable technologies. Our main process filtration products include:

• Sartopore 2, Sartobran P and Sartolon membrane filters - scalable membrane filtration for highest yield and outstanding performance
• MidiCaps and MaxiCaps - disposable filtration units to reduce cleaning validation
• GammaSart biosystems - disposable bag container assemblies for media preparation and storage
• LevTech mixing system - levitated mixing in sterile bag systems
• Sartocheck integrity test systems - state of the art integrity test systems

SERVICES – VALIDATION SERVICE, PROCESS OPTIMIZATION, TRAINING SERVICE, REGULATORY COMPLIANCE

Sartorius provides a full range of value added services for its BioPharm Alliance, addressing critical success factors of the biopharmaceutical industry like time to market, cost of goods, production capacity and regulatory compliance.