NeoMPS - Peptide Synthesis and GMP Manufacturing

NeoMPS, a unique organization formed by the alliance of Neosystem (France) and Multiple Peptide Systems (California), is your gateway to the exciting world of peptides.

The companies were started independently in 1986 on two different continents. Over the years they have developed, in parallel, extensive experience and practical know-how in peptide manufacturing.

As a leading worldwide manufacturer of peptides and related services, NeoMPS provides easy access to custom research grade peptides, clinical grade peptides (GMP), custom antipeptide antibodies and a catalogue of over 2,000 bioactive peptides, natural and special protected amino acids and building blocks. Over the years we have successfully manufactured more than 70,000 research grade peptides and over 400 GMP grade peptides, several of them in multi-kilogram batches.

At NeoMPS, we thrive at providing our clients with an unparalleled array of services in peptide manufacturing built on a tradition of technological expertise and pioneering spirit. The synergy between the two companies, in terms of facility utilization and capabilities, geographical location, regulatory liaison and a full spectrum of technologies (solid phase, solution phase, combination of chemistries, etc.) applicable to the production of GMP peptides, makes NeoMPS a premier partner for the development of new peptides for the pharmaceutical industry.

PEPTIDE SYNTHESIS

NeoMPS supplies the simplest to the most complex research tools, including:

• Nearly 800 bioactive peptides and enzyme substrates and inhibitors
• Custom research peptides: research up to pilot scale quantities can be provided in a variety of predefined purity levels, including any modifications (cyclization, biotinylation, phosphorylation, labelling with fluorescent dyes, etc.)
• Custom polyclonal antipeptide antibodies
• Research and Development services, e.g. lead optimisation and process development for future scale-up, custom peptide libraries and custom radio labelled peptides

ORGANIC CHEMISTRY FROM RESEARCH TO PILOT SCALE

Our specific catalogue includes over 550 special amino acids and derivatives, building blocks and turn mimics, all available from stock. Custom organic chemicals can also be developed in house.

We can also provide custom synthesis of non-peptidic molecules, from several grams to several hundreds of grams and cGMP manufacturing at kilogram scale.

Six chemistry labs are dedicated to chemistry of amino acids, peptides in solution or general organic chemistry. Development trials can be performed in a pilot plant (200-litre reactor).

GMP MANUFACTURING - ACTIVE PHARMACEUTICAL INGREDIENTS (APIs)

NeoMPS supplies APIs from gram to tens of kilograms.

Quality Assurance and Regulations - the manufacture of GMP grade peptides conforms to ICH Q7A Good Manufacturing Practices for APIs – CFR Part 210, 211 and 820 and EudraLex Volume 4, Part II.

Facilities in Europe and North America - GMP grade peptides can be manufactured in either facility: San Diego, California or Strasbourg, France. The flexibility of the production site can be of great interest for our customers, depending on the location of their clinical trials and regulatory filings. Furthermore, two facilities assure our clients stability in production.

Experience with GMP peptides in clinical trials, Phase I-III and commercial application - NeoMPS, Inc. has been manufacturing GMP grade peptides since 1990 and NeoMPS SA opened its GMP production facility in 1998. Nearly 400 GMP peptides (APIs, medical device components, diagnostic components) have been prepared to date with several approved for commercial applications. Production capacity is gram to multi-kilogram quantities per batch.

Full regulatory support - NeoMPS provides complete assistance during drug development: stability studies of the active ingredient and/or the clinical trial material; assistance with formulation development; support with regulatory filings, either in the form of a technical report (CTD format) which serves as the CMC section of the IND or complete preparation and maintenance of a DMF

The North American (US) plant is registered and inspected by the US FDA, Korean FDA, and approved by Japan’s Ministry of Health, Labor and Welfare, while the European (France) site inspected for GMP compliance by the French Health Products Safety Agency (AFSSAPS) in accordance with Directive 2001/83/EC.

Our objective: building long-term relationships with our clients through personal attention and flexibility.

See also Drug Development Technology - NeoMPS - Peptide Manufacturing and Related Chemicals