Japanese-based Eisai has received a positive opinion from the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) on lenvatinib mesylate in combination with everolimus, to treat adult patients with advanced renal cell carcinoma (RCC).

To be launched under the brand name Kisplyx, the anti-cancer agent lenvatinib mesylate can treat adult RCC patients after one prior vascular endothelial growth factor (VEGF) targeted therapy.

Discover B2B Marketing That Performs

Combine business intelligence and editorial excellence to reach engaged professionals across 36 leading media platforms.

Find out more

Lenvatinib is an orally administered, multiple receptor tyrosine kinase (RTK) inhibitor with an effective binding mode that particularly inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors and fibroblast growth factor (FGF) receptors.

"Advanced or metastatic RCC is currently difficult to treat with surgery, while the basic treatment method is molecular targeted drug therapy with five years of low survival rates."

The drug inhibits the additional proangiogenic and oncogenic pathway-related RTKs that includes the platelet-derived growth factor (PDGF) receptor PDGFRalpha, KIT, and RET, involved in tumour proliferation.

Advanced or metastatic RCC is currently difficult to treat with surgery, while the basic treatment method is molecular targeted drug therapy with five years of low survival rates.

At present, Lenvatinib, under the product name Lenvima, has been introduced in several countries across the world that includes the US, Japan and different nations in Europe for treating patients with refractory thyroid cancer.

GlobalData Strategic Intelligence

US Tariffs are shifting - will you react or anticipate?

Don’t let policy changes catch you off guard. Stay proactive with real-time data and expert analysis.

By GlobalData

In May this year, lenvatinib, in combination with everolimus, was approved by the US Food and Drug Administration (FAA) to treat patients with advanced RCC after one prior VEGF-targeted therapy.

Pharmaceutical Technology Excellence Awards - The Benefits of Entering

Gain the recognition you deserve! The Pharmaceutical Technology Excellence Awards celebrate innovation, leadership, and impact. By entering, you showcase your achievements, elevate your industry profile, and position yourself among top leaders driving pharmaceutical advancements. Don’t miss your chance to stand out—submit your entry today!

Nominate Now