Avutometinib potassium is under clinical development by Verastem and currently in Phase II for Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer (HER2- Breast Cancer). According to GlobalData, Phase II drugs for Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer (HER2- Breast Cancer) have a 49% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Avutometinib potassium’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Avutometinib potassium overview

Avutometinib potassium (RG-7304, RO5126766) is under development for the treatment of solid tumors including low-grade serous ovarian cancer (LGSOC) , peritoneal cancer, fallopian tube cancer, metastatic uveal melanoma, brain metastases from cutaneous melanoma, metastatic pancreatic cancer, pancreatic ductal adenocarcinoma, metastatic adenocarcinoma of the pancreas, non-small cell lung cancer, multiple myeloma, glioblastoma, recurrent glioblastoma, endometrial cancer, prostate cancer, cervical cancer, HER2 negative breast cancer, anaplastic thyroid cancer, papillary thyroid carcinoma, follicular thyroid carcinoma and colorectal cancer. It is administered orally as a capsule. It is a new molecular entity (NME) with a structure based on a coumarin skeleton. The drug candidate acts by targeting B-Raf kinase, C-Raf kinase, mitogen activated protein kinase kinase 1 (MEK-1 or MAP2K1). It was also under development for melanoma, pancreatic cancer and solid tumors in Japan.

Verastem overview

Verastem is a late-stage development biopharmaceutical company that discovers, develops, and commercializes novel small molecule drugs to treat cancer. The company’s product candidates include VS-6766, defactinib (VS-6063). Verastem products VS-6766 and defactinib (VS-6063), are being investigated in both preclinical and clinical studies for the treatment of various solid tumors, including, low-grade serous ovarian cancer (LGSOC), non-small cell lung cancer (NSCLC), colorectal cancer (CRC), pancreatic cancer, uveal melanoma, and endometrial cancer.The company operates in Germany and the US. Verastem is headquartered in Needham, Massachusetts, the US.

For a complete picture of Avutometinib potassium’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 22 January 2024

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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.