BioGaia has patented a method for adapting anaerobic microorganisms to oxygen, creating new probiotics. By inducing oxidative stress through voltage and oxygen diffusion, and adjusting antioxidant levels, the method selects more oxygen-tolerant strains like Faecalibacterium prausnitzii. The adapted strains show increased tolerance to ambient air. GlobalData’s report on BioGaia gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on BioGaia, Lactobacillus probiotics was a key innovation area identified from patents. BioGaia's grant share as of May 2024 was 46%. Grant share is based on the ratio of number of grants to total number of patents.
Oxygen adapted strain of anaerobic microorganism for probiotics
A recently granted patent (Publication Number: US11976268B2) discloses a method for producing an oxygen-adapted strain of an anaerobic microorganism, specifically Faecalibacterium prausnitzii. The method involves subjecting anaerobic microorganisms to a stepwise dual induction of oxidative stress by adjusting voltage, oxygen diffusion, and antioxidant concentration to increase oxygen tolerance. The resulting oxygen-adapted strain shows enhanced tolerance to ambient air compared to the original strain.
The patent claims detail the specific conditions and parameters involved in the process, such as the selection of antioxidant/oxidized counterpart pairs like cysteine/cystine, and the starting conditions for the culture medium. The method includes steps for culturing and selecting the oxygen-adapted strain under specific voltage, oxygen diffusion, and antioxidant/oxidized counterpart concentration ratios. Additionally, the patent specifies the reinoculation of anaerobic microorganisms into new culture mediums at each step to produce the oxygen-adapted strain. Furthermore, the patent identifies specific strains of oxygen-adapted Faecalibacterium prausnitzii, such as DSM 32380, DSM 32378, and DSM 32379, as part of the invention. Overall, the patent provides a detailed and specific method for creating oxygen-adapted anaerobic microorganism strains, particularly Faecalibacterium prausnitzii, with increased oxygen tolerance.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
