NNV1 is an oncolytic virus commercialized by Calidi Biotherapeutics, with a leading Phase I program in Recurrent Glioblastoma Multiforme (GBM). According to Globaldata, it is involved in 3 clinical trials, of which 1 was completed, 1 is ongoing, and 1 is planned. GlobalData uses proprietary data and analytics to provide a complete picture of NNV1’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.

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The revenue for NNV1 is expected to reach an annual total of $15 mn by 2040 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

NNV1 Overview

NNV1 is under development for the treatment of recurrent glioblastoma multiforme (GBM), anaplastic astrocytoma, gliosarcoma, anaplastic oligodendroglioma, anaplastic oligoastrocytoma, metastatic ovarian cancer, newly diagnosed high-grade glioma and recurrent high-grade glioma. The therapeutic candidate comprises immortalized neural stem cells (NSC) loaded with oncolytic adenovirus (CRAd-S-pk7). It is administered through intracerebral route and is being developed based on NeuroNova platform.

It was also under development for the treatment of malignant glioma.

Calidi Biotherapeutics Overview

Calidi Biotherapeutics is an immuno-oncology company focusing on developing and commercializing efficient stem cell-based platforms for cancer treatment. The company is headquartered in San Diego, California, the US.
The operating loss of the company was US$23.1 million in FY2022, compared to an operating loss of US$10.5 million in FY2021. The net loss of the company was US$25.4 million in FY2022, compared to a net loss of US$10.9 million in FY2021.

For a complete picture of NNV1’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.

This content was updated on 10 June 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.