Photocure has been granted a patent for a method of photodynamic therapy (PDT) for bladder cancer, using hexyl 5-ALA ester (HAL) and blue light. The therapy is intended as an adjuvant treatment for non-muscle invasive bladder cancer (NMIBC) post-transurethral resection. GlobalData’s report on Photocure gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Photocure, Photodynamic cancer therapy drugs was a key innovation area identified from patents. Photocure's grant share as of May 2024 was 46%. Grant share is based on the ratio of number of grants to total number of patents.
A recently granted patent (Publication Number: US11980772B2) outlines a method of photodynamic therapy as an adjuvant treatment for non-muscle invasive bladder cancer (NMIBC). The method involves instilling an aqueous solution containing hexyl 5-ALA ester (HAL) or a salt thereof into the patient's bladder post transurethral resection of NMIBC. The bladder is then exposed to blue light within specific parameters, including fluence rate and light dose, to achieve therapeutic effects.
Furthermore, the patent details variations in the exposure to blue and white light, the use of a blue-light cystoscope as a light source, and the duration of light exposure. The method of photodynamic therapy described in the patent can potentially replace or complement existing adjuvant therapies like chemotherapy, immunotherapy, or Bacillus Calmette-Guerin (BCG) treatment, particularly in BCG refractory patients. The composition used in the therapy consists of HAL in an aqueous buffer, with specific pH and concentration ranges outlined for optimal efficacy. The patent aims to provide a novel approach to treating NMIBC, offering a potentially effective alternative for patients who may not respond to traditional treatments.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
