Siltuximab is under clinical development by Recordati and currently in Phase II for Pain. According to GlobalData, Phase II drugs for Pain have a 45% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Siltuximab’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Siltuximab overview

Siltuximab (Sylvant), is an anti-IL-6 chimeric monoclonal antibody. It is formulated as lyophilized powder for solution for intravenous administration. It is indicated for the treatment of adult patients with multicentric Castleman’s disease (MCD) who are human immunodeficiency virus (HIV) negative and human Herpesvirus-8 (HHV-8) negative metastatic pancreatic adenocarcinoma and pancreatic cancer. 

Siltuximab (Sylvant, CNTO-328) is under development for the treatment of  coronavirus disease (COVID-19),pain. It is also under development for the treatment multiple myeloma and AL amyloidosis. It was also under development for the treatment of metastatic renal cell carcinoma, B-cell non-Hodgkin lymphoma, metastatic hormone refractory prostate cancer, myelodysplastic syndrome, refractory and relapsed multiple myeloma and smoldering multiple myeloma (SMM).

Recordati overview

Recordati, a subsidiary of Fimei SpA, is a pharmaceutical company that researches, develops, manufactures and markets pharmaceuticals. The company offers pharmaceuticals for cardiovascular diseases, central nervous system disorders, dermatology, musculoskeletal disorders and analgesia, and urology diseases. It also offers cosmetics, dietary supplements, pregnancy test products, over-the-counter (OTC) and non-prescription pharmaceuticals, anti-infectives, and others. It manufactures pharmaceutical chemicals such as active pharmaceutical ingredients (APIs) and intermediates. The company sells its pharmaceuticals directly in the countries of its operations and through licensees in other places. Recordati is headquartered in Milan, Italy.

For a complete picture of Siltuximab’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 7 February 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.