Singular Genomics Systems. has been granted a patent for compositions and methods designed to deplete nucleotide impurities in nucleotide solutions. The claimed composition includes labeled nucleotide triphosphates, a depletion polynucleotide, and specific polymerases for selective incorporation during sequencing processes. GlobalData’s report on Singular Genomics Systems gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Singular Genomics Systems, DNA polymerase compositions was a key innovation area identified from patents. Singular Genomics Systems's grant share as of June 2024 was 30%. Grant share is based on the ratio of number of grants to total number of patents.
Methods for depleting nucleotide impurities in solutions
The granted patent US12031179B2 outlines a novel composition designed for nucleic acid sequencing applications. The primary components of this composition include labeled nucleotide triphosphates with distinct functional groups: those featuring a free 3'-OH and those with a 3' reversible terminator moiety. Additionally, the composition incorporates a non-immobilized depletion polynucleotide, which consists of a depletion primer hybridized to a depletion template, and a depletion polymerase that selectively incorporates the 3'-OH nucleotide triphosphates while being incapable of incorporating the reversible terminator moiety. The composition also includes a sequencing primer hybridized to an immobilized polynucleotide and a sequencing polymerase that can utilize both types of labeled nucleotide triphosphates.
Further claims detail specific characteristics of the composition, such as storage conditions, the structure of the depletion polynucleotide, and the nature of the reversible terminator moiety. The patent specifies that the depletion polynucleotide may consist of homopolymer sequences or hairpin structures, and it can include various nucleotide sequences. The claims also highlight the identity of the depletion polymerase's amino acid sequence and the relative quantities of the labeled nucleotide triphosphates. Overall, this patent presents a comprehensive framework for a sequencing composition that enhances the efficiency and specificity of nucleic acid sequencing processes.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
