The Splenic Marginal Zone B-Cell Lymphoma drugs in development market research report provides comprehensive information on the therapeutics under development for Splenic Marginal Zone B-Cell Lymphoma, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA), and molecule type. GlobalData’s report assesses key aspects of the companies and drugs in development for Splenic Marginal Zone B-Cell Lymphoma. Buy the report here.

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The report also covers the descriptive pharmacological action of the therapeutics and the latest news and press releases. Additionally, the report provides an overview of the key players involved in therapeutic development for Splenic Marginal Zone B-Cell Lymphoma and features dormant and discontinued products.

GlobalData tracks 33 drugs in development for Splenic Marginal Zone B-Cell Lymphoma by 29 companies/universities/institutes. The top development phase for Splenic Marginal Zone B-Cell Lymphoma is phase ii with 19 drugs in that stage. The Splenic Marginal Zone B-Cell Lymphoma pipeline has 28 drugs in development by companies and five by universities/ institutes. Some of the companies in the Splenic Marginal Zone B-Cell Lymphoma pipeline products market are: BeiGene, F. Hoffmann-La Roche and General Hospital of the People’s Liberation Army.

The key targets in the Splenic Marginal Zone B-Cell Lymphoma pipeline products market include Cells Expressing B Lymphocyte Antigen CD19 (B Lymphocyte Surface Antigen B4 or Differentiation Antigen CD19 or T Cell Surface Antigen Leu 12 or CD19), Tyrosine Protein Kinase BTK (Bruton Tyrosine Kinase or B Cell Progenitor Kinase or Agammaglobulinemia Tyrosine Kinase or BTK or EC 2.7.10.2), and Phosphatidylinositol 4,5 Bisphosphate 3 Kinase Catalytic Subunit Delta Isoform (PI3K-Delta or Phosphatidylinositol 4,5 Bisphosphate 3 Kinase 110 kDa Catalytic Subunit Delta or PIK3CD or EC 2.7.1.137 or EC 2.7.1.153).

The key mechanisms of action in the Splenic Marginal Zone B-Cell Lymphoma pipeline product include Cytotoxic To Cells Expressing B Lymphocyte Antigen CD19 (B Lymphocyte Surface Antigen B4 or Differentiation Antigen CD19 or T Cell Surface Antigen Leu 12 or CD19) with 11 drugs in Phase III. The Splenic Marginal Zone B-Cell Lymphoma pipeline products include six routes of administration with the top ROA being Intravenous and four key molecule types in the Splenic Marginal Zone B-Cell Lymphoma pipeline products market including Small Molecule, and Gene-Modified Cell Therapy.

Splenic Marginal Zone B-Cell Lymphoma overview

Splenic marginal zone lymphoma (SMZL) is a rare type of B-cell lymphoma that affects the spleen, bone marrow, and sometimes the blood. It is a low-grade neoplasm that originates from the germinal centers of the splenic white pulp. The neoplastic cells are small lymphocytes and larger transformed lymphoblasts that invade the mantle and marginal zones of the spleen and erode its normal architecture. SMZL may be associated with hepatitis C virus infection in some cases. The diagnosis of SMZL requires the presence of splenomegaly and splenic histology. The bone marrow may show nodular infiltration by neoplastic cells with marginal zone differentiation. Peripheral blood may contain villous lymphocytes with plasmacytoid features. SMZL is an indolent disease that may not require immediate treatment unless symptoms or cytopenias are present. Rituximab-based therapies are effective in most patients, and novel agents are being investigated for relapsed or refractory cases.

For a complete picture of Splenic Marginal Zone B-Cell Lymphoma’s pipeline drug market, buy the report here.

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GlobalData’s pipeline drugs offers detailed profiles of pharmaceutical drugs in all stages of pre-clinical and clinical development, from discovery through to pre-registration. Coverage is limited to novel human medicinal drugs and biosimilars seeking market approval proprietary and is one of two primary repositories of pharmaceutical drug information offered by GlobalData through its Pharmaceutical Intelligence Center.