Synlogic has been granted a patent for genetically engineered bacteria that produce short-chain fatty acids to attenuate metabolic diseases. The bacteria are designed to respond to specific environmental conditions in the mammalian gut. GlobalData’s report on Synlogic gives a 360-degree view of the company including its patenting strategy. Buy the report here.
According to GlobalData’s company profile on Synlogic, Peptide pharmacophores was a key innovation area identified from patents. Synlogic's grant share as of February 2024 was 18%. Grant share is based on the ratio of number of grants to total number of patents.
Genetically engineered bacteria for attenuating metabolic diseases
A recently granted patent (Publication Number: US11896627B2) discloses a bacterium engineered to produce short-chain fatty acids, specifically butyrate, propionate, or acetate, in response to environmental conditions found in the mammalian gut. The bacterium also includes a gene for producing indole-3-acetaldehyde. The patent claims cover various aspects of the engineered bacterium, including the presence of specific promoters induced by low-oxygen or anaerobic conditions, the use of plasmids or chromosomes for gene cassette and promoter placement, and the inclusion of a kill switch or toxic substance gene for safety measures.
Furthermore, the patent extends to a pharmaceutically acceptable composition containing the engineered bacterium and a carrier, formulated for oral administration to treat metabolic diseases or disorders. The specified conditions for treatment include type 1 diabetes, type 2 diabetes, metabolic syndrome, and a range of genetic syndromes affecting metabolism. The composition aims to leverage the engineered bacterium's ability to produce beneficial short-chain fatty acids in response to gut environmental cues to potentially address a variety of metabolic conditions effectively. The patent highlights the potential of probiotic or commensal bacteria, such as Bacteroides, Bifidobacterium, Clostridium, Escherichia, Lactobacillus, and Lactococcus, in therapeutic applications for metabolic disorders.
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