United Therapeutics has patented an apparatus for blood purification using a membrane with vascular and filtration channel systems. The invention also includes methods for making the apparatus and membranes. GlobalData’s report on United Therapeutics gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on United Therapeutics, Cancer treatment biomarkers was a key innovation area identified from patents. United Therapeutics's grant share as of February 2024 was 44%. Grant share is based on the ratio of number of grants to total number of patents.

Apparatus for pancreatic function restoration using membrane with cell systems

Source: United States Patent and Trademark Office (USPTO). Credit: United Therapeutics Corp

A recently granted patent (Publication Number: US11918955B2) discloses an innovative apparatus designed to restore or supplement pancreatic function. The apparatus comprises a functional unit with a membrane separating two channel systems, one of which is populated with pancreatic islet cells to generate functional pancreatic tissue. The membrane is a biocompatible extracellular matrix membrane embedded into a matrix material, with specific characteristics such as a minimum shear stress and transmembrane pressure. The apparatus also includes biological fluid inflow and outflow conduits, vascular channel walls lined with endothelial cells, and can be configured with multiple functional units stacked in parallel layers.

Moreover, the patent details methods for treating patients with insufficient pancreatic function using the apparatus, either by implanting it in the patient or operating it extracorporeally. The manufacturing process involves creating membranes with sacrificial material for the channel systems, submerging them in a scaffold material solution, gelating the material, removing the sacrificial material to form luminal spaces, and populating the second channel system with pancreatic islet cells. This method can also include populating the first channel system with endothelial cells, further enhancing the functionality of the apparatus for pancreatic treatment. Overall, the patent presents a comprehensive approach to addressing pancreatic insufficiency through a sophisticated apparatus and method, offering potential benefits for patients in need of pancreatic function restoration or supplementation.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies