Zodasiran is an antisense rnai oligonucleotide commercialized by Arrowhead Pharmaceuticals, with a leading Phase II program in Homozygous Familial Hypercholesterolemia (HoFH). According to Globaldata, it is involved in 7 clinical trials, of which 2 were completed, 1 is ongoing, and 4 are planned. GlobalData uses proprietary data and analytics to provide a complete picture of Zodasiran’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.

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The revenue for Zodasiran is expected to reach an annual total of $42 mn by 2035 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

Zodasiran Overview

AROANG-3 is under development for the treatment of dyslipidemic patients including familial hypercholesterolemia including homozygous familial hypercholesterolemia and heterozygous familial hypercholesterolemia (heFH), severe hypertriglyceridemia, familial chylomicronemia syndrome and mixed dyslipidemia. It is administered through subcutaneous route. The therapeutic candidate is a siRNA acts by targeting angiopoietin-like 3 protein (ANGPTL3). The drug candidate is developed based on targeted RNAi molecule (TRiM) platform.

Arrowhead Pharmaceuticals Overview

Arrowhead Pharmaceuticals (Arrowhead) is a biotech company that develops and commercializes gene silencing therapeutics. The company utilizes RNA chemistries and TRiM platform to target and silence disease-causing genes. Its pipeline products include ARO-AAT, ARO-APOC3, ARO-ANG3, ARO-PNPLA3, GSK4532990, ARO-C3, ARO-ENaC2, ARO-MUC5AC, ARO-RAGE, ARO-MMP7, ARO-COV, ARO-DUX4, ARO-SOD1, HZN-457, JNJ-3989 and Olpasiran. Arrowhead’s therapeutic areas include hypertriglyceridemia, dyslipidemia, facioscapulohumeral muscular dystrophy, complement-mediated diseases, much-obstructive or inflammatory pulmonary conditions, idiopathic pulmonary fibrosis, liver disease, gout, chronic hepatitis B and cardiovascular disease, among others. The company operates lab facilities in San Diego, California and Madison, Wisconsin, the US. Arrowhead is headquartered in Pasadena, California, the US.
The company reported revenues of (US Dollars) US$240.7 million for the fiscal year ended September 2023 (FY2023), a decrease of 1% over FY2022. The operating loss of the company was US$205 million in FY2023, compared to an operating loss of US$178.5 million in FY2022. The net loss of the company was US$205.3 million in FY2023, compared to a net loss of US$176.1 million in FY2022. The company reported revenues of US$3.6 million for the first quarter ended December 2023, a decrease of 77.9% over the previous quarter.

For a complete picture of Zodasiran’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.

This content was updated on 10 June 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.