Pharmagel Engineering develops Softgel Technology for pharmaceutical, nutraceutical and cosmetic products.
Softgel - protection for oral dosage potency and shelf-life
The softgel (soft gelatine) capsule is a one piece, hermetically sealed shell wall filled with oils and non-acqueos liquids, plus solids in a paste or solution form.
The shell gives a unique strength and durability to softgels, and in addition protects the inner fill material from atmospheric oxidation that compromises other oral dosage forms in terms of potency and shelf-life.
Softgel has become widely used in prescription and OTC pharmaceuticals, plus also in nutraceuticals, because of the following advantages:
- Improved bioavailability
- Easier to swallow
- Better consumer confidence
- Elegant appearance
- Masks odours
- Longer shelf life
- Rapid action
- Easy and flexible formulation
Semi-turnkey softgel encapsulation plants
Pharmagel is the leading supplier of semi-turnkey softgel encapsulation plants worldwide, having been engaged in the research and development of encapsulation lines and the formulation of softgels for four decades.
Pharmagel softgel encapsulation equipment is used in 24 countries on 5 continents. Many of the plants have been completely redesigned and supplied with technology and training by Pharmagel. This experience combined with our many decades of experience in the industrial production of softgels, enables Pharmagel to give clients a unique and unrivalled guarantee of industrial manufacturing success in their own markets.
The Pharmagel range of softgel encapsulation lines and ancillary equipment, combined with Pharmagel's technology and knowledge of the worldwide softgel market, offers clients a service of unrivalled quality and capability. That is especially important with the increasing use of softgels over the past two decades in the pharmaceutical, nutraceutical, cosmetic and leisure industries.
Softgel encapsulation machinery
The MK3 range of Softgel lines represent a new generation of rotary die encapsulation machines designed to comply with international GMP and with the capability to make all capsule types, with a performance capability of up to 450 million softgels per year (typical 7.5 minim oval size).
Pharmagel production process
Fill and capsule base preparation - These two phases are the key for a successful encapsulation process. Using the example of the most complex fill type, complex pastes such as multivitamins /minerals or herbal extracts; these must be processed with proper specification mixing, refining and homogenising equipment and procedure, under vacuum. Particle size and viscosity are optimised for easy and accurate encapsulation. GMP equipment design with proven CIP (clean in place) systems is also vital to avoid cross contamination between products.
Capsule base preparation is a critical process as it directly affects capsule shape, appearance and seam strength.
Encapsulation and drying - Encapsulation is obviously the most critical phase for the production of a perfect softgel capsule batch. The rotary die process, which has been perfected by Pharmagel over 4 decades, is a continuous single operation, because with the rotary die process the softgel capsule is formed and filled in a single step under conditions of low humidity and accurately controlled temperature.
Following encapsulation, softgels undergo drying - firstly fluid bed drying for approximately two hours followed by one to three days tray drying.
Inspection - With pharmagel technology, batches require little inspection and sorting with Pharmagel automatic sorting machines specially designed to automatically inspect capsules at high speed and with minimal labour costs.
Pharmagel Guarantee – advanced technologies and equipment, GMP encapsulation plant design, accurate selection of capsule raw materials, intelligent choice of excipients, and experienced design of formulations.
We outline below our project technology transfer services:
- Preliminary Plant layout
- Design and drawing of a complete softgel manufacturing facility
- Detailed technical documentation
- Supply of all manufacturing, ancillary and analytical equipment
- Provide operation manuals and Sop’s
- Supervise Plant design and equipment installation
- Installation qualification (I.Q.) and operational qualification (O.Q.)
- New softgel capsule product formulation and manufacturing procedures
- Experimental trials
- Pilot batch production
- Stability tests
- Product master files in accordance with the requirements of major international health authorities