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Tablet Press Manufacture for Compaction Simulation and Powder Analysis

Medelpharm is a high-precision engineering company manufacturing research and development (R&D) tablet presses and providing innovative solutions for powder analysis and formulation.

615 rue du Chat Botté,
ZAC des Malettes,
F-01700 BEYNOST,

Medelpharm is a specialist in the development, design, and manufacture of research and development (R&D) tablet presses for powder compression.

This high-precision engineering company provides intelligent tablet press technology and software development solutions for powder analysis and formulation

Medelpharm focuses on continuous development of innovative research presses (hardware and software), compaction simulation of industrial production cycles, powder characterisation and formulation services, compression, and material science in the pharmaceutical, food, and cosmetics markets.

R&D press for tablet development

The new STYL’One Evolution tableting instrument is a high-speed, all-in-one multilayer tool designed for use in tablet development from early formulation to scale-up at production speed.

Multi tip tooling on STYL’One Nano Benchtop Press.
Mini tablets patient-friendly systems for paediatric and geriatric applications.
STYL’One Nano Benchtop press powder zone and smart gravity feed shoe.
STYL’One Evo and STYL’One Nano R&D Presses.
STYL’One Evo - Enhanced operator Safety.
STYL’One Evo Full Containment OEB 5 GMP installation.
External lubrication puff box and micro dosing unit.
Calibrated manual lubrication spray.
STYL’One Evo Roll Compaction Profile | Ribblet (Ribbon tablet).
STYL’One Nano R&D Benchtop Press | Easy change of tooling.

The machine characterises essential powder properties and active pharmaceutical ingredients (API). It tests their suitability by simulating industrial production cycles, typically up to 400,000 tab/hour (dwell time <2ml), with only a few grams of powder needed.

Machine operator protection during tablet production

Making no compromises on user protection during tableting, from early research to multilayer production scale-up, Medelpharm follows a global trend. The company offers different levels of operator protection from wash-in-place to full containment OEL 5 for the most potent drug substances.

Dry granulation compaction for small scale development

Dry granulation with roll compaction hybrid modelling is a topic intensively pursued by Medelpharm in close cooperation with the University of Düsseldorf.

Quality by Design (QbD) R&D tablet press

QbD is a concept to produce a drug in a repeatable and cost-effective way. The QbD concept is in the heart of the design and develpment of the STYL’One R&D tablet press.

Powder compaction analysis software

The ANALIS data acquisition and control package automatically explores and analyses the design of formula with efficiency in investigating critical attributes.

Collected data is analysed and presented in a user-friendly tabular or graphical format.

Tablet compaction and powder analysis

The STYL’One Evolution is easy to use, with a compact, door-size design. It offers a clean and easy exchange of B, D (EU │TSM) oversized, core rods.

Valuable accessories are available such as the micro-dosing unit, a tab-in-tab device, a good manufacturing practice (GMP) module with weight regulation and force feeding, and a heated die.

STYLCAM / STYL’One has been installed more than 100 times worldwide and users are still enjoying ease of-use with no trade-off.

Training courses for tablet formulation and production

Medelpharm offers a range of training courses that are recognised by French authorities. The company aims to offer its extensive knowledge through effective training.

Medelpharm also offers its professional tableting instruments to various universities for training purposes so students can gain experience on current and future working methods. The company has university partnerships worldwide.

Maintenance, FAT, and SAT

Medelpharm offers services such as URS definition, installation, FAT, SAT, training and support, maintenance, and calibration, as well as consumables and wear and tear parts.

Powder processing solutions

Medelpharm distributes renowned and innovative technologies in powder processing from lab-scale to production with brands such as supplier of special process machines LB Bohle, manufacturer and developer of equipment for the production of pellets Caleva, and manufacturer of pharmaceutical hammer mills Fitzpatrick.

Conical mill for particle size reduction and uniform tableting

Quadro designs and manufactures leading technology for uniform size reduction, sieving, deagglomaration and dispersion.

Procept offers a comprehensive range of lab scale R&D particle processing equipment for drying, agglomeration, coating and mixing applications.

Laboratory services

In mid-2017, Medelpharm decided to leave its laboratory in the heart of the University of Lyon and built a laboratory on its own premises. This laboratory has a controlled atmosphere so it can perform powder characterisation and analysis.

It also houses innovative measuring equipment such as the STYL’One Tableting Instrument, Smart Test 50, a CALEVA mini coater, a Quadro SLS multifunctional scalable lab system and a Comil U5, as well as an Accupyc (Micromeritics) Helium Pycnometer to measure true density, a turbula mixer, a disintegration bath and a friability tester.

About Medelpharm

Medelpharm is headquartered in Lyon, South-East France. Its team of experienced scientists provide powder characterisation services for screening of numerous formulations and testing powder flowability, powder densities, and tabletability.

Styl’One Nano

The new STYL’One Nano is a revolutionary benchtop R&D press for demanding formulation and scientists with price performance in mind.

Medelpharm STYL’One Evolution

The STYL'One Evolution is the only press you will ever require from initial formulation characterisation of API to high-speed multilayered scale-up.

Material Characterization on STYL’One Nano

This case study will illustrate how STYL’One Nano can be an efficient tool for scientists to demonstrate material properties, securing their formulation development and their product marketing.

STYL’One Nano: The Most Advanced Benchtop Tablet Press

Tableting has never been so easy and so powerful, from pure API characterisation to formulation assessment. Single-punch presses are ideal at formulation stage: easy to operate, easy to clean and for small amounts of API.

Containment: A Must-Have in Tableting

STYL’One stands for no compromise on tabletting analysis and no compromise on user protection from early research to multilayer production scale-up.

Webinar: External Lubrication on STYL’One Evo

Save-the-date. On 17 February, Medelpharm will be presenting its next webinar “External Lubrication: How to mitigate the impact of lubricants on your quality attributes”, featuring Cedrine de Backere, Ghent University.

28 January 2021

Alix Integrated R&D Software Platform

Medelpharm is pleased to announce the release of Alix, an innovative integrated worldwide R&D platform for demanding formulation scientists.

9 June 2020

Medelpharm Launched Alix at AAPS PharmSci 360, Texas

Research-based manufacturer and powder compaction specialist Medelpharm launched Alix, its new global development platform, at the American Association of Pharmaceutical Scientists annual meeting, AAPS PharmSci 360, in San Antonio, Texas.

11 November 2019

Tablet & Capsules Hands-On Short Course

MEDELPHARM's strategic marketing director Regis Cazes (MS, MBA) has been invited to speak at the 'Tablet & Capsules Hands-On Short Course' hosted by the University of Maryland School of Pharmacy.

1 October 2018

Tablet Development Hands-On Session

Medelpharm has announced a hands-on session about compaction simulation, compression profiles and how to solve capping issues through pre-compression, compression speed and producing bi-layer tablets and tab-in-tab.

20 August 2018

Medelpharm to Exhibit at ACHEMA

Medelpharm will be showcasing its latest research and development (R&D) tablet press machines and powder analysis and formulation solutions at the ACHEMA tradeshow in Frankfurt am Main, Germany.

29 May 2018

Medelpharm to Exhibit at FCE Pharma, Sao Paolo

Medelpharm will be exhibiting its latest research and development (R&D) tablet presses and solutions for powder analysis and formulation at the FCE Pharma Expo, Sao Paolo, Brazil.

8 May 2018

Medelpharm to Attend CPhI Frankfurt

Medelpharm has announced it will be showcasing the renowned STYL'One Evolution tableting instrument with its latest innovative accessories at CPhI Frankfurt.

9 October 2017


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