Powder Systems Limited (PSL) High-Containment Powder Handling and Advanced Process Solutions

Agitated nutsche filter dryer

PSL is an international manufacturer of filtration, drying and high-containment solutions from small-scale production to full process systems for pharmaceutical, biopharmaceutical, chemical, specialty chemical, armed forces and laboratory industries worldwide. PSL provides advanced containment processes for the production of highly potent APIs, including cytotoxic, oncology, hormones, sterile and many other active compounds.

Our products range from laboratory synthesis to commercial production equipment, including filters, filter dryers, vacuum dryers, tray dryers, isolators and gloveboxes. Our solutions enable clients to bring new generation drugs into the market place faster, using the latest technology in containment and production equipment.

Laboratory glass filter dryer for lab-scale synthesis

PSL’s leading laboratory glass filter dryer (GFD®) technology is designed for easy lab-scale filtration and drying. The GFD works on a vacuum and has a heated jacket for drying. The innovative PSL removable filtration basket allows total product collection, without having to dig the cake out of the vessel. The GFD is a miniature version of a production filter dryer, allowing simple lab filtration and drying with the same reliability and benefits as full-size filter dryers.

Agitated nutsche filter dryers for filtration and drying

PSL’s filtration solutions include a large range of agitated nutsche filter dryers that are designed to perform efficient filtration and drying of highly potent APIs and cytotoxic powder. Our metallic filter dryers, ranging from laboratory and R&D to full-scale production, provide optimum levels of safety and quality and are designed to meet industry regulations. Contained offloading is performed through the unique PSL discharging isolator, allowing complete heel removal of the product from the vessel.

Pressure filter / vacuum filter for simple filtration

PSL’s simplefilter is a pressured filter plate, a simplified alternative to more complex and costly technologies, designed for many pharmaceutical and chemical applications, including hydrogenation, carbon filtration, catalyst recovery, pre-filter for micro-filtration, APIs and intermediate filtration. The simplefilter has a jacketed swing-out base for efficient drying and uncomplicated removal of the product. For maximum flexibility and adaptability, PSL’s simplefilter is fully mobile, allowing you to move it freely between different areas.

Vacuum tray dryer for uniform drying

PSL drying solutions include the patent pending CakeStand tray dryer. This vacuum drying oven incorporates a unique heat transfer system, generating perfect heat uniformity across all heating plates for the drying of powder. The tray dryer can be incorporated within a PSL glovebox isolator system when drying highly potent product. PSL tray dryers are designed from laboratory to production scale, and can meet sterile process requirements.

Powder handling solutions and isolation systems

PSL containment solutions comprise a full range of gloveboxes and isolators enabling users to perform numerous potent operations, safely. Our isolation systems provide proven containment to nanogram level for the handling of highly potent powder, whilst protecting the operator, the product and the environment.

PSL’s contained powder handling solutions include dispensing and sampling; charging powder in a reactor, vessel and drum filling; and filtration, drying and offloading / discharging. PSL gloveboxes and isolators can include interchangeable mills, micronising, sieving and blending systems in one total formulation facility.

High-containment lab glass filtration and drying technology

PSL now provides world-leading high-containment lab glass filtration and drying technology as part of its existing FilterBox range. This revolutionary technology consists of a small to large-scale agitated nutsche filter dryer (or GFD), which is completely integrated within a PSL isolator, providing high containment when handling highly potent APIs and other highly active or cytotoxic compounds.

PSL starts 2013 by supporting the fast-growing market of microsphere. Our process experts have developed unique filtration systems to produce microsphere, small spherical particles with diameters in the micrometer range. New applications for microspheres are discovered every day, especially in the field of cancer research and the biopharmaceutical industry.

We have been established for more than 24 years and are one of the original pioneers of high containment systems. We have business operations across the world, including in the US, the UK, France, Czech Republic and India, and a growing distribution network.

For more information about PSL’s advanced process solutions, please contact us and we will be happy to discuss any process requirements you may have.

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Press Release

Latest Technology in Microsphere Formulation Process

How can new technology improve the productivity of your microsphere formulation process? Powder Systems Limited (PSL) is hosting a free webinar on 13 February presenting new technologies and process solutions for microsphere formulation.

White Papers

Designing Isolator with Reliability

Why do reliable and efficient high containment systems continue to challenge the pharmaceutical industry? This article considers the reasons for this, highlighting possible working methods and design considerations to overcome some of the issues faced.

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Press Release

23 January 2014

How can new technology improve the productivity of your microsphere formulation process? Powder Systems Limited (PSL) is hosting a free webinar on 13 February presenting new technologies and process solutions for microsphere formulation.

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2 December 2013

PSL is to exhibit at PMEC India this week, on stand F50, Hall 6 of the Bombay Exhibition Centre, Mumbai.

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31 October 2013

PSL has won two high-profile manufacturing awards in as many months.

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14 August 2013

Powder Systems Limited (PSL) is pleased to announce two exciting projects in Spain. The company recently delivered a high containment installation in the country and will soon start the manufacture of a range of isolators for another client's Spanish manufacturing site.

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8 August 2013

Microspheres are small spherical particles, having a required size range typically 5µm up to 250µm. These particles can be manufactured from various natural and synthetic materials such as polymer microspheres.

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10 April 2013

As a simplified alternative to more complex and costly technologies, the simplefilter is designed for many pharmaceutical and chemical applications such as: hydrogenation, carbon filtration, catalyst recovery, pre-filter for micro-filtration, APIs and intermediate filtration.

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11 February 2013

As a pioneer of containment, Powder Systems Limited (PSL) has refined a complete range of contained vessel charging solutions that will protect both the operator and the product down to nanograms containment level.

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Regional Offices

PSL USA

Cliffside Research Park

3944 N. Mountain View Drive, STE 100

Boise, ID 83704

United States of America

+1 208 376 7008 +1 208 376 7999
PSL France

5 Rue de Brest

69002 Lyon

France

+33 9534 04448
PSL India

No. 001 Shree Building

Shailendra Nagar Road, Overi Pada

Dahisar (East) Mumbai 400 068

India

+91 22 28908232
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