Belzutifan is under clinical development by Merck and currently in Phase II for Metastatic Castration-Resistant Prostate Cancer (mCRPC). According to GlobalData, Phase II drugs for Metastatic Castration-Resistant Prostate Cancer (mCRPC) have a 33% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Belzutifan’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Belzutifan overview

Belzutifan (Welireg) is an anti-cancer agent. It is formulated as film-coated tablets, coated tablets for oral route of administration. Welireg is indicated for the treatment of adult patients with von Hippel-Lindau (VHL) disease who require therapy for associated renal cell carcinoma (RCC), central nervous system (CNS) hemangioblastomas, or pancreatic neuroendocrine tumors (pNET), not requiring immediate surgery.

MK-6482 (PT-2977) is under development for the treatment of clear cell renal cell carcinoma (ccRCC), gastrointestinal stromal tumor (GIST), von Hippel-Lindau disease-associated renal cell carcinoma, human epidermal growth factor receptor 2-negative (ER+/HER2-) unresectable metastatic breast cancer  pancreatic ductal adenocarcinoma, hepatocellular carcinoma, endometrial cancer, esophageal squamous cell carcinoma, colorectal cancer, bile duct cancer (cholangiocarcinoma), gallbladder cancer, clear cell renal cell carcinoma, metastatic renal cell carcinoma, advanced pheochromocytoma/paraganglioma (PPGL), pancreatic neuroendocrine tumor (pNET), recurrent glioblastoma multiforme, metastatic castration-resistant prostate cancer (mCRPC) and rare cancers. It is a small molecule. It is administered through oral route. The drug candidate targets hypoxia-inducible factor-2 alpha (HIF-2alpha). It was also under development for the treatment of iron overload (hemosiderosis) and pulmonary arterial hypertension.

Merck overview

Merck is a biopharmaceutical company with focus on the discovery, development, manufacturing and marketing of prescription medicines, biologic therapies, vaccines, and animal health products. It offers prescription products for the treatment of cardiovascular conditions, cancer, immune disorders, infectious and respiratory diseases, and diabetes, among others. The company provides animal health products such as vaccines, poultry products, livestock products and aquaculture products. Merck sells medicines to drug wholesalers, retailers, hospitals, government agencies and managed health care providers; and animal health products to veterinarians, distributors, and animal producers. The company and its subsidiaries operate in the Americas, Europe, the Middle East, Africa, Asia Pacific, and Latin America. Merck is headquartered in Rahway, New Jersey, the US.

For a complete picture of Belzutifan’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 10 June 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.