Fazirsiran sodium is an antisense rnai oligonucleotide commercialized by Takeda Pharmaceutical, with a leading Phase III program in Alpha-1 Antitrypsin Deficiency (A1AD). According to Globaldata, it is involved in 7 clinical trials, of which 2 were completed, and 5 are ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of Fazirsiran sodium’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.

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The revenue for Fazirsiran sodium is expected to reach an annual total of $68 mn by 2035 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

Fazirsiran sodium Overview

ARO-AAT is under development for the treatment of liver disease associated with alpha-1 antitrypsin deficiency (AATD). The drug candidate is administered through subcutaneous route. It is a N-acetylgalactosamine-conjugated synthetic double-stranded oligomer specific to serpin family A member 1 gene. It is a follow-on product candidate of ARC-AAT targeting the mutant alpha-1antitrypsin (Z-AAT) protein and is developed based on RNAi platform technology.

Takeda Pharmaceutical Overview

Takeda Pharmaceutical (Takeda) is a research-based pharmaceutical company, which focuses on the discovery, development, manufacturing, marketing, commercialization, import and export of drugs. It provides treatment for inflammatory bowel disease, acid-related diseases, motility disorders and liver diseases; hemophilia and hereditary bleeding disorders; primary immunodeficiency and multifocal motor neuropathy; major depressive disorder and attention-deficit hyperactivity disorder; and its cancer treatment encompasses multiple myeloma, mantle cell lymphoma, non-small cell lung cancer and chronic myeloid leukemia. It markets products directly and through a network of wholesale distributors, retail chains and other purchasing groups worldwide. Takeda has partnership with academic institutions, small biotech, and large pharmaceutical companies. It has presence in the Americas, Europe, and Asia, among others. Takeda is headquartered in Tokyo, Japan.
The company reported revenues of (Yen) JPY4,263,762 million for the fiscal year ended March 2024 (FY2024), an increase of 5.9% over FY2023. In FY2024, the company’s operating margin was 5%, compared to an operating margin of 13.2% in FY2023. In FY2024, the company recorded a net margin of 3.4%, compared to a net margin of 7.9% in FY2023.

For a complete picture of Fazirsiran sodium’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.

This content was updated on 10 June 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.