Iodine i 131 apamistamab is under clinical development by Actinium Pharmaceuticals and currently in Phase III for Refractory Acute Myeloid Leukemia. According to GlobalData, Phase III drugs for Refractory Acute Myeloid Leukemia have a 57% phase transition success rate (PTSR) indication benchmark for progressing into Pre-Registration. GlobalData’s report assesses how Iodine i 131 apamistamab’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Iodine i 131 apamistamab overview

Iomab-B, a radioimmunoconjugate (BC8-I-131 construct) is under development for the treatment of relapsed and refractory follicular lymphoma, chronic lymphocytic leukemia, high-grade B-cell lymphoma, diffuse large B-cell lymphoma, relapsed and refractory B-cell acute lymphoblastic leukemia and chronic myeloid leukemia (CML), acute myelocytic leukemia (AML), acute lymphoblastic leukemia, myelodysplastic syndrome, myeloproliferative disorders, relapsed and/or refractory elderly acute myeloid leukemia, chronic myelomonocytic leukemia, refractory anemia with excess blasts, cytopenia, multiple myeloma and refractory anemia with ringed sideroblasts and for prevention of lymphodepletion during CAR-T therapy. The drug candidate is also under development for bone marrow conditioning before a hematopoietic stem cell transplant (HSCT), in relapsed/refractory elderly AML patients. It is administered parenterally through intravenous route. The drug is a radionuclide drug conjugate (RDC) which consists of monoclonal antibody apamistamab and the beta emitting radioisotope I131 (I-131). It acts by targeting CD45 and is developed by using Alpha Particle Immunotherapy, Antibody Warhead Enabling (AWE) Technology platform. It was also under development for Hodgkin lymphoma, relapsed/refractory B-non-Hodgkin lymphoma (B-NHL), T-non-Hodgkin lymphoma(T-NHL) and mantle cell lymphoma.

Actinium Pharmaceuticals overview

Actinium Pharmaceuticals (Actinium) develops antibody radiation conjugates (ARC), which combine antibodies’ targeting ability with radiation’s cell-killing ability. The company’s pipeline products include Iomab-B for hematopoietic stem cell transplantation, Iomab-ACT for treating GeneTx and Cell therapy conditioning and Actimab-A(CD33) for treating relapsed/refractory AML. Its three variants of Actimab-A developed by the company are- Actimab-A (CD33) and CLAG-M; Actimab-A (CD33) and Venetoclax and Actimab-A (CD33) and Venetoclax with HMA. ATNM is headquartered in New York City, New York, the US.

For a complete picture of Iodine i 131 apamistamab’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 10 June 2024

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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.